Effect of L-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial
Effect of L-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial
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DOI：
10.1159/000335470
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发表时间：
2012-01-01
影响因子：
3.9
通讯作者：
Gargari, Bahram Pourghassem
中科院分区：
文献类型：
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作者：
Alizadeh, Mohammad;Safaeiyan, Abdolrasoul;Gargari, Bahram Pourghassem
背景/目标：我们的目的是发现L-精氨酸和硒单独或一起是否可以增加富含豆类的低热量饮食（HDEL）对中心性肥胖和心血管危险因素的影响。方法：这项随机、双盲、安慰剂对照试验在84名绝经前中心性肥胖妇女中进行。经过2周的等热量饮食的磨合期后，参与者被随机分配到对照饮食（HDEL），L-精氨酸（5 g/天）和HDEL，硒（200 μ g/天）和HDEL或L-精氨酸，硒和HDEL 6周。在干预前和干预后3周和6周评估心血管危险因素。结果如下：6周后，L-精氨酸显著降低腰围（WC）;硒显著降低空腹血清胰岛素浓度和胰岛素抵抗指数; L-精氨酸和硒交互作用显著降低空腹一氧化氮（NOx）浓度，HDEL降低甘油三酯（TG）和WC，显著升高空腹NOx浓度。HDEL在研究的前半部分降低了高敏C反应蛋白水平，并在后半部分将其恢复到基础水平。结论：这些数据表明L-精氨酸对中心性肥胖、硒对胰岛素抵抗和HDEL对血清NOx和TG浓度的有益作用。版权所有（C）2012 S. Karger AG，巴塞尔
Background/Aims: We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. Methods: This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on an isocaloric diet, participants wee randomly assigned to a control diet (HDEL), L-arginine (5 g/day) and HDEL, selenium (200 mu g/day) and HDEL or L-arginine, selenium and HDEL for 6 weeks. Cardiovascular risk factors were assessed before intervention and 3 and 6 weeks afterwards. Results: After 6 weeks, L-arginine had significantly reduced waist circumference (WC); selenium had significantly lowered fasting concentrations of serum insulin and the homeostasis model assessment of insulin resistance index; the interaction between L-arginine and selenium significantly reduced the fasting concentration of nitric oxides (NOx), and HDEL lowered triglycerides (TG) and WC and significantly increased the fasting concentration of NOx. HDEL reduced high-sensitivity C-reactive protein levels in the first half of the study and returned them to basal levels in the second half. Conclusion: These data indicate the beneficial effects of L-arginine on central obesity, selenium on insulin resistance and HDEL on serum concentrations of NOx and TG. Copyright (C) 2012 S. Karger AG, Basel