Use of VEPs as electrodiagnostic biomarkers of mild cognitive impairment
Use of VEPs as electrodiagnostic biomarkers of mild cognitive impairment
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DOI：
10.1111/ncn3.12387
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发表时间：
2020-03
影响因子：
0.4
通讯作者：
T. Yamasaki
中科院分区：
文献类型：
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作者：
T. Yamasaki
阿尔茨海默病（AD）及其前驱疾病轻度认知障碍（MCI）的特征在于早期发作的视觉空间障碍沿着记忆障碍和定向障碍。基于这些临床特征，我假设视力损害可能是MCI早期电诊断的候选生物标志物。因此，我一直专注于应用视觉诱发电位（VEP）作为一种无创，简单，客观的方法来评估MCI患者的视觉障碍。在这篇综述中，我首先概述了人类视觉系统的概念。其次，简要介绍了虚拟企业的基本技术。然后，我描述了以往的视觉诱发电位研究AD和MCI。这些VEP研究报告说，较低水平的视觉通路不太可能参与AD和MCI，而较高水平的视觉流经常显示VEP异常。最后，我介绍了我的新的视觉诱发电位技术检查视觉障碍的MCI。具有多模态视觉刺激（特别是光流运动）的VEP可用于区分MCI患者与非受损个体。区分导致MCI的痴呆类型也是可行的。从这篇综述中，我强调VEP是MCI早期电诊断的合理生物标志物。
Alzheimer's disease (AD) and its precursor, mild cognitive impairment (MCI), are characterized by early onset of visuospatial impairment along with memory impairment and disorientation. Based on these clinical features, I hypothesized that visual impairment might be a candidate biomarker for early electrodiagnosis of MCI. Therefore, I have been focusing on the application of visual evoked potentials (VEPs) as a non‐invasive, simple, and objective method for evaluating visual impairment in MCI patients. In this review, I first outline the concept of the human visual system. Second, I briefly mention the basic technology of VEPs. Then, I describe the previous VEP studies on AD and MCI. These VEP studies have reported that the lower‐level visual pathways are less likely to be involved in AD and MCI, whereas the higher‐level visual streams frequently show VEP abnormalities. Finally, I introduce my new VEP techniques for examining visual impairment in MCI. VEPs with multimodal visual stimuli (especially, optic flow motion) are useful for distinguishing MCI patients from non‐impaired individuals. It may also be feasible to discriminate the type of dementia responsible for MCI. From this review, I stress that VEPs are plausible biomarkers for the early electrodiagnosis of MCI.