Clinical characteristics and prognosis of non-B non-C hepatocellular carcinoma patients with modest alcohol consumption.
Clinical characteristics and prognosis of non-B non-C hepatocellular carcinoma patients with modest alcohol consumption.
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适度饮酒的非B非C型肝细胞癌患者的临床特征和预后。
DOI：
10.1111/hepr.12572
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Sakaida I.
中科院分区：
文献类型：
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作者：
Urata Y;Yamasaki T;Saeki I;Iwai S;Kitahara M;Sawai Y;Tanaka K;Aoki T;Iwadou S;Fujita N;Nakayama Y;Maeshiro T;Takami T;Sakaida I.
目的酒精性肝细胞癌（ALD‐HCC）占非B非C型HCC（NBNC‐HCC）病例的大多数。虽然酒精是一种强致癌物，但关于NBNC-HCC中适度饮酒的影响的报道很少。本研究旨在探讨NBNC-HCC患者的临床特点和预后与适度的酒精consumption.MethodsFrom 2007年至2010年，2283 HCC患者在10家医院进行了评估。我们收集了588 NBNC-HCC患者的详细病因数据，并比较了ALD-HCC和适度酒精-HCC patients.ResultsThere的临床特征和预后有69 HCC患者适度饮酒，占所有HCC患者的3%评估。该患者组的女性明显更多，Child-Pugh A级、高血压和晚期疾病的患病率更高，并且在年龄较大时被诊断为HCC，而ALD-HCC组（266例患者）。此外，在中度酒精肝细胞癌患者中，糖尿病在抗B核心（HBc）阴性亚组中比在抗HBc阳性亚组中更常见。然而，无论肿瘤分期的显著差异如何，两组患者的生存率均无显著差异。酒精消费和代谢因素是没有显着的独立预测survival.ConclusionThe中度酒精肝细胞癌的临床特征包括先进的分期，良好的肝脏储备能力和年龄较大的诊断。适度饮酒患者的HCC发展可能与代谢因素有关。虽然大约30%的评估的HCC病例处于晚期，但适度饮酒的NBNC-HCC患者的预后相对有利。
AimAlcoholic hepatocellular carcinoma (ALD‐HCC) accounts for the majority of non‐B non‐C HCC (NBNC‐HCC) cases. Although alcohol is a potent carcinogen, there have been few reports on the influence of modest alcohol consumption in NBNC‐HCC. This study aimed to investigate the clinical characteristics and prognosis of NBNC‐HCC patients with modest alcohol consumption.MethodsFrom 2007 to 2010, 2283 HCC patients were evaluated at 10 hospitals. We collected detailed etiology data of 588 NBNC‐HCC patients and compared the clinical characteristics and prognosis between ALD‐HCC and modest alcohol‐HCC patients.ResultsThere were 69 HCC patients with modest alcohol consumption, accounting for 3% of all HCC patients evaluated. This patient group had significantly more women and higher prevalence of Child–Pugh class A, hypertension and advanced disease stage, and were diagnosed with HCC at an older age than the ALD‐HCC group (266 patients). Additionally, among the modest alcohol‐HCC patients, diabetes was significantly more common in the anti‐hepatitis B core (HBc) negative subgroup than in the anti‐HBc positive subgroup. However, no significant difference in survival was observed between the two patient groups regardless of significant differences in tumor staging. Alcohol consumption and metabolic factors were not significant independent predictors of survival.ConclusionThe clinical characteristics of modest alcohol‐HCC included advanced staging, favorable liver reserve capacity and older age at diagnosis. HCC development in patients with modest alcohol consumption may relate to metabolic factors. Although approximately 30% of the evaluated HCC cases were in advanced stages, the prognosis of NBNC‐HCC patients with modest alcohol consumption was relatively favorable.