Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents
Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents
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DOI：
10.1126/science.281.5374.266
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发表时间：
1998-07-10
期刊：
影响因子：
56.9
通讯作者：
Chen, ISY
中科院分区：
文献类型：
--
作者：
Poon, B;Grovit-Ferbas, K;Chen, ISY
人类免疫缺陷病毒1型（HIV-1）Vpr在T细胞生产性感染后的表达诱导细胞周期停滞在细胞周期的G（2）期。在没有从头表达的情况下，HIV-1 Vpr包装到病毒体中仍然诱导细胞周期停滞。天然非感染性病毒或逆转录酶或蛋白酶抑制剂导致感染缺陷的病毒能够诱导Vpr介导的细胞周期停滞。这些结果表明，感染性和非感染性病毒粒子在体内，如周围的滤泡树突状细胞，参与免疫抑制的模型。
Expression of human immunodeficiency virus-type 1 (HIV-1) Vpr after productive infection of T cells induces cell cycle arrest in the G(2) phase of the cell cycle. In the absence of de novo expression, HIV-1 Vpr packaged into virions still induced cell cycle arrest. Naturally noninfectious virus or virus rendered defective for infection by reverse transcriptase or protease inhibitors were capable of inducing Vpr-mediated cell cycle arrest. These results suggest a model whereby both infectious and noninfectious virions in vivo, such as those surrounding follicular dendritic cells, participate in immune suppression.