Comprehensive analysis of the prognosis for chromobox family in gastric cancer
Comprehensive analysis of the prognosis for chromobox family in gastric cancer
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DOI：
10.21037/jgo-20-208
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发表时间：
2020-10-01
影响因子：
2.1
通讯作者：
Zhu, Zhengming
中科院分区：
文献类型：
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作者：
Lin, Kang;Zhu, Jinfeng;Zhu, Zhengming
背景：Chromobox (CBX) 家族蛋白是一类转录抑制蛋白，参与多种肿瘤（包括胃癌）的表观遗传调控和发育过程。然而，不同CBXs在胃癌中的功能和预后仍不清楚。方法：本研究通过综合目前包含大量肿瘤样本并提供非常可靠的分析结果的几个主流数据库（Oncomine、GEPIA2、cBioportal和Kaplan-Meier绘图仪等）来探讨CBXs在胃癌预后中的作用。结果：CBX1/2/3/4/5/8的mRNA在胃癌中高表达， CBX7 mRNA 在胃癌中低表达，CBX6 mRNA 在结直肠癌中表达无显着差异。此外，CBXs mRNA 的高低表达与 CRC 患者的癌症分期、淋巴结转移状态、幽门螺杆菌感染状态和肿瘤分级相关。我们发现，在大量 CRC 患者中，CBX4/5/6/7/8 的高 mRNA 表达与较差的总生存期 (OS)、无进展生存期 (FP) 和进展后生存期 (PPS) 显着相关。 CBX3 的高 mRNA 表达与更好的 OS 和 FP 显着相关。我们还发现，8个CBXs家族基因在胃癌中的突变率均不低于5%，突变率最高的是CBX3（14%）。结论：这些结果表明CBX3/4/5/6/7/8可以作为胃癌患者的预后生物标志物。
Background: Chromobox (CBX) family proteins are a class of transcriptional repressors involved in epigenetic regulation and developmental processes of various tumors, including gastric cancer. However, the function and prognosis of different CBXs in gastric cancer remain unknown.Methods: This study addresses this issue by synthesizing several mainstream databases (Oncomine, GEPIA2, cBioportal, and Kaplan-Meier plotter, among others) that currently contain many tumor samples and provide very reliable analysis results, investigating the role of CBXs in the prognosis of gastric cancer.Results: The mRNA of CBX1/2/3/4/5/8 was highly expressed in gastric cancer, the mRNA of CBX7 was lowly expressed in gastric cancer, and the mRNA expression of CBX6 was not significantly different in CRC. Besides, high and low CBXs mRNA expression correlated with cancer stage, node metastasis status, H. pylori infection status, and tumor grade in CRC patients. We found that high mRNA expression of CBX4/5/6/7/8 was significantly associated with worse overall survival (OS), progression-free survival (FP), and post-progression survival (PPS) in a large number of CRC patients. High mRNA expression of CBX3 was significantly associated with better OS and FP. We also found that none of the eight CBXs family genes had a mutation rate of less than 5% in gastric cancer, and the highest mutation rate was in CBX3 (14%).Conclusions: These results suggest that CBX3/4/5/6/7/8 could be a prognostic biomarker in gastric cancer patients.