Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits
Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits
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DOI：
10.1016/s0021-9150(01)00740-7
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发表时间：
2002-06-01
期刊：
影响因子：
5.3
通讯作者：
Giuliano, F
中科院分区：
文献类型：
--
作者：
Behr-Roussel, D;Bernabe, J;Giuliano, F
衰老和动脉粥样硬化（ATH）是众所周知的勃起功能障碍（艾德）的危险因素。为了确定与AT诱导的ED无关的机制，我们研究了（i）体内勃起反应。60例青年（YAD，n = 6）、成年（AD. 11 = 6）。和胆固醇喂养的（ATH，n = 8）新西兰白色兔。测量ATH兔髂动脉内膜中膜（1，M）比率，确定中度（ModATH。0.5+/- 0.3）或重度（严重ATH，1.5 +/-0.4，P < 0.05 Mann-Whitney）动脉粥样硬化病变。与YAD兔相比，AD兔的勃起反应降低（6 V至10 Hz：51.6+/-4.6%，vs. 57.5 +/-1.4%），AD和中度ATH兔的勃起反应相似（48.1 +/-4.6%，vs. 57.5 +/-1.4%，P < 0.05），但Se ATH兔的勃起反应明显受损（34.8 +/-5.4%，P < 0.05）。双因素方差分析（ANOVA））。YAD和AD兔的体内皮依赖性和非依赖性舒张功能相当（对乙酰胆碱的最大舒张：51.3 +/-9.5% vs. 56.1 +/- 9.3%），但ATH组降低，表明ATH诱导艾德的机制是兔（37.1 +/-1.6%，P
Ageing and atherosclerosis (ATH) are well-known risk factors for erectile dysfunction (ED). To identify the mechanisms implicated in ATH-induced ED. independently of its ageing-associated component, we studied (i) erectile responses in vivo. and, 60 endothelium-dependent and independent relaxations of corporal strips from young adult (YAD, n = 6), adult (AD. 11 = 6). and cholesterol-fed (ATH, n = 8) New-Zealand white rabbits. Measurement of Intima Media (1, M) ratio on iliac arteries from ATH rabbits determined those with moderate (Mod ATH. 0.5 +/- 0.3) or severe (Sev ATH, 1.5 +/-0.4, P < 0.05 Mann-Whitney) atherosclerotic lesions. Erectile response,,, were reduced in AD compared with YAD rabbits (at 6 V to 10 Hz: 51.6+/-4.6%,, vs. 57.5 +/- 1.4%) them ere similar in AD and mod ATH rabbits (48.1 +/- 4.6%) but drastically impaired in Se ATH rabbits (34.8 +/- 5.4%, P < 0.05. two-way analysis of variance (ANOVA)). Corporal endothelium-dependent and -independent relaxations were comparable in YAD and AD rabbits (maximal relaxation to acetylcholine: 51.3 +/- 9.5 vs. 56.1 +/- 9.3%) but decreased in ATH est that the mechanisms implicated in ATH-induced ED are rabbits (37.1 +/- 1.6%, P