CAPSAICIN-INDUCED VASODILATATION OF HUMAN CORONARY-ARTERIES INVITRO IS MEDIATED BY CALCITONIN GENE-RELATED PEPTIDE RATHER THAN SUBSTANCE-P OR NEUROKININ-A
CAPSAICIN-INDUCED VASODILATATION OF HUMAN CORONARY-ARTERIES INVITRO IS MEDIATED BY CALCITONIN GENE-RELATED PEPTIDE RATHER THAN SUBSTANCE-P OR NEUROKININ-A
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DOI：
10.1111/j.1748-1716.1989.tb08704.x
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发表时间：
1989-08-01
期刊：
影响因子：
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通讯作者：
RUDEHILL, A
中科院分区：
文献类型：
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作者：
FRANCOCERECEDA, A;RUDEHILL, A
在本研究中，辣椒素对人动脉冠状动脉张力在体外的可能影响进行了研究，与降钙素基因相关肽（CGRP），P物质（SP）或神经激肽A（NKA）的血管舒张特性。此外，还观察了血管活性肠肽（VIP）和生长抑素（SOM）对动脉的影响。CGRP应用于钾预收缩的人心外膜冠状动脉（内径0.4-0.6 mm）诱导浓度依赖性的持久舒张。SP也松弛这些预收缩的动脉，但松弛是短暂的，快速耐受性在重复给药后迅速发展。SP快速耐受不影响CGRP的舒张作用。此外，预孵育棉酚，内皮衍生的舒张因子（EDRF）的形成和释放的抑制剂，完全取消了SP的影响，而不影响CGRP的舒张作用。NKA仅引起预收缩动脉的非常轻微的松弛。VIP和SOM均呈浓度依赖性地舒张预收缩动脉。辣椒素引起钾预收缩动脉的松弛。这种效应不受SP快速耐受或棉酚孵育的影响。因此，CGRP而不是SP模拟辣椒素对人冠状动脉的血管舒张作用。这表明CGRP而不是SP可能介导心脏感觉神经激活后观察到的舒张作用。
In the present study the possible influence of capsaicin on human arterial coronary tone in vitro was studied in relation to the vasodilatory properties of calcitonin gene-related peptide (CGRP), substance P (SP) or neurokinin A (NKA). In addition, the influence of vasoactive intestinal polypeptide (VIP) and somatostatin (SOM) on the arteries was investigated. CGRP application to potassium-pre-contracted human epicardial coronary arteries (0.4-0.6 mm in inner diameter) induced a concentration-dependent, long-lasting relaxation. SP also relaxed these pre-contracted arteries, but the relaxation was transient and tachyphylaxis developed rapidly upon repeated administration. SP tachyphylaxis did not influence the relaxatory effects of CGRP. Furthermore, pre-incubation with gossypol, an inhibitor of the formation and release of endothelium-derived relaxing factors (EDRF), completely abolished the effects of SP without influencing the dilatory action of CGRP. NKA only induced a very minor relaxation of the pre-contracted arteries. Both VIP and SOM concentration-dependently relaxed the pre-contracted arteries. Capsaicin evoked a relaxation of the potassium-pre-contracted arteries. This effect was not influenced by SP tachyphylaxis or gossypol incubation. Thus, CGRP but not SP mimics the vasodilatory effects of capsaicin on human coronary arteries. This suggests that CGRP rather than SP is likely to mediate the relaxatory effects seen upon activation of cardiac sensory nerves.