Role of Physical Activity in Bone-Muscle Crosstalk: Biological Aspects and Clinical Implications.
Role of Physical Activity in Bone-Muscle Crosstalk: Biological Aspects and Clinical Implications.
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DOI：
10.3390/jfmk6020055
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发表时间：
2021-06-21
影响因子：
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通讯作者：
Tarantino U
中科院分区：
文献类型：
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作者：
Cariati I;Bonanni R;Onorato F;Mastrogregori A;Rossi D;Iundusi R;Gasbarra E;Tancredi V;Tarantino U
骨和肌肉组织通过机械和生化信号的整合相互影响，产生骨-肌串扰。它们还分泌骨因子、肌因子和细胞因子进入循环，影响局部和远处器官和细胞的生物和病理活动。在这方面，即使最初被认为是两种独立疾病的骨质疏松症和肌肉减少症，最近也被定义为“骨质减少症”，以表明骨量低与肌肉萎缩和功能减退的协同状态。毫无疑问，骨骼肌减少症是一个主要的公共卫生问题，与高发病率和死亡率有关。目前预防骨骼肌减少症的最佳方法是通过健康的生活方式和定期锻炼进行预防。对骨骼肌减少症产生积极影响的最合适的运动类型、强度、持续时间和频率尚不清楚。然而，渐进式阻力运动、负重冲击运动和挑战性平衡/移动活动的组合方案目前似乎是优化肌肉骨骼健康和功能的最有效方案。基于这一证据，我们综述的目的是总结目前关于运动在骨肌相声中的作用的知识，强调它如何可能代表一种有效的替代策略来预防和/或抵消骨骨骼肌减少症的发作。
Bone and muscle tissues influence each other through the integration of mechanical and biochemical signals, giving rise to bone–muscle crosstalk. They are also known to secrete osteokines, myokines, and cytokines into the circulation, influencing the biological and pathological activities in local and distant organs and cells. In this regard, even osteoporosis and sarcopenia, which were initially thought to be two independent diseases, have recently been defined under the term “osteosarcopenia”, to indicate a synergistic condition of low bone mass with muscle atrophy and hypofunction. Undoubtedly, osteosarcopenia is a major public health concern, being associated with high rates of morbidity and mortality. The best current defence against osteosarcopenia is prevention based on a healthy lifestyle and regular exercise. The most appropriate type, intensity, duration, and frequency of exercise to positively influence osteosarcopenia are not yet known. However, combined programmes of progressive resistance exercises, weight-bearing impact exercises, and challenging balance/mobility activities currently appear to be the most effective in optimising musculoskeletal health and function. Based on this evidence, the aim of our review was to summarize the current knowledge about the role of exercise in bone–muscle crosstalk, highlighting how it may represent an effective alternative strategy to prevent and/or counteract the onset of osteosarcopenia.