Extensive axonal Lewy neurites in Parkinson's disease:: a novel pathological feature revealed by α-synuclein immunocytochemistry
Extensive axonal Lewy neurites in Parkinson's disease:: a novel pathological feature revealed by α-synuclein immunocytochemistry
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DOI：
10.1016/s0304-3940(99)00208-6
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发表时间：
1999-04-09
影响因子：
2.5
通讯作者：
Braak, E
中科院分区：
文献类型：
--
作者：
Braak, H;Sandmann-Keil, D;Braak, E
路易体和粗糙的路易神经节是帕金森病（PD）患者脑内神经元变性的病理标志。最近，突触前蛋白α-突触核蛋白被证明是路易体和路易神经突的主要成分。本研究首次证明了广泛和薄的α-突触核蛋白免疫反应性包涵体存在于神经元的轴突过程。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Lewy bodies and coarse Lewy neu rites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions a re present in the axonal processes of neurons. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.