Blood hemoglobin level and treatment outcome of early breast cancer
Blood hemoglobin level and treatment outcome of early breast cancer
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DOI：
10.1007/s00066-004-1123-7
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发表时间：
2004-01-01
影响因子：
3.1
通讯作者：
Schumacher, M
中科院分区：
文献类型：
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作者：
Henke, M;Sindlinger, F;Schumacher, M
背景和目的：为了确定血液血红蛋白浓度是否与早期乳腺癌患者的预后相关，如果是的话，这是否局限于治疗方式。（T1，2 NO-2 MO）接受保乳手术后辅助放疗（BCS-RT; n = 96）或改良根治性乳房切除术（MRM; n = 194）。术前血液血红蛋白水平，淋巴结状态，组织学分级和激素受体状态对无病生存的影响，确定两种治疗方式使用考克斯回归模型和可视化KapLan-Meier plots.Results：血液血红蛋白浓度显着相关的无病生存的患者接受BCS-RT（相对风险[RR]：0.67每克/分升; p = 0.007）。这是独立于其他已知的乳腺癌患者的危险因素，如多变量分析确定。相比之下，血液血红蛋白水平没有预后意义时，患者接受MRM。结论：血液血红蛋白浓度似乎影响早期乳腺癌患者的预后时，包括放疗的治疗方案。由于肿瘤氧合减少导致的放射敏感性降低可能是根本原因。有必要进行旨在阐明潜在机制的验证性试验和研究。
Background and Purpose: To determine whether the blood hemoglobin concentration correlates with the prognosis of patients with early breast cancer and, if so, whether this is restricted to treatment modality.Patients and Methods: Data were collected retrospectively from patients with early breast cancer (T1,2 NO-2 MO) who underwent either breast-conserving surgery followed by adjuvant radiotherapy (BCS-RT; n = 96) or a modified radical mastectomy (MRM; n = 194). The effect of preoperative blood hemoglobin Level, nodal status, histological grading and hormone receptor status on disease-free survival was determined for both treatment modalities using a Cox regression model and visualized by KapLan-Meier plots.Results: The blood hemoglobin concentration significantly correlated with disease-free survival of patients receiving BCS-RT (relative risk [RR]: 0.67 per g/dL; p = 0.007). This was independent of other known risk factors for breast cancer patients, as determined by multivariate analysis. By contrast, the blood hemoglobin Level had no prognostic significance when patients were treated with MRM.Conclusion: Blood hemoglobin concentration seems to affect the prognosis of patients with early breast cancer when a treatment schedule that includes radiotherapy is applied. Reduced radiosensitivity due to diminished tumor oxygenation may be the underlying cause. Confirmative trials and studies intended to elucidate the underlying mechanism are warranted.