In-vitro studies of jet injections
In-vitro studies of jet injections
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DOI：
10.1016/j.ijpharm.2019.118503
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发表时间：
2019-09-10
影响因子：
5.8
通讯作者：
Marston, Jeremy O.
中科院分区：
文献类型：
--
作者：
Rohilla, Pankaj;Marston, Jeremy O.
本研究以均匀明胶为模型基质，对无针喷射注射动力学进行了研究。在保持喷嘴直径(DO)和安瓶体积(V)不变的情况下，我们研究了距离(S)、凝胶周围的限制、模型凝胶的储存模数(G‘)和液体粘度(Mu)对喷射穿透深度的影响。利用高速成像技术观察液体射流的传播和弥散动力学，采用称重传感器测量不同距离和不同液体粘度下的冲击力。考虑的不同参数对侵彻深度有显著影响，其中对靶距的非线性依赖是关键结果，这可能对未来的喷射器设计有一定的指导意义。此外，禁闭的影响是对使用明胶底物作为人体组织替代品的谨慎。
In this study, needle-free jet injection dynamics were studied using homogeneous gelatin as model substrates. Whilst keeping nozzle properties such as orifice diameter (do) and ampoule volume (V) constant, we demonstrate the effect of standoff (s), confinement around the gel, storage modulus (G') of model gel and liquid viscosity (mu) on the penetration depth of the jet injection. High-speed imaging was used to observe the liquid jet propagation and dispersion dynamics, whilst a load cell was implemented to measure the impact force for different standoff distance and viscosity of the liquid. The different parameters considered showed significant effects on penetration depth, with non-linear dependence on standoff being the key result, which may have implications for future injector designs. Moreover, the effect of confinement serves as a caution of using gelatin substrates as a proxy for human tissue.