Apparent lack of association of COVID-19 vaccination with Herpes Zoster.
Apparent lack of association of COVID-19 vaccination with Herpes Zoster.
复制标题
DOI：
10.1016/j.ajoc.2022.101549
复制
发表时间：
2022-06
影响因子：
--
通讯作者：
Cohen, Elisabeth J
中科院分区：
文献类型：
--
作者：
Patil, Sachi A;Dygert, Levi;Galetta, Steven L;Balcer, Laura J;Cohen, Elisabeth J
带状疱疹（HZ）已被确定为与BNT 162 b2 COVID-19疫苗接种的潜在关联。本研究在接受疫苗接种的患者队列中评估了这种可能的关联。对2020年1月12日至2021年9月30日期间在纽约大学Langone Health接受至少一次COVID-19疫苗接种的成年患者的Epic电子健康记录进行了审查，以分析疫苗接种前3个月内与疫苗接种后3个月内带状疱疹的新诊断。在接受至少一次COVID-19疫苗接种的596，111名患者中，716名患者在疫苗接种前3个月内被诊断患有HZ，而781名患者在疫苗接种后3个月内被诊断。使用卡方检验确定比例的独立性，接种前（比例：0.0012，95% CI：[0.0011，0.0013]）与接种后（比例：0.0013，95% CI：[0.0012，0.0014]）的HZ频率无统计学显著性差异;（p = 0.093）。这项研究没有发现COVID-19疫苗接种与HZ新诊断之间存在关联的证据。我们鼓励医护专业人士根据疾病控制中心（CDC）的建议强烈推荐接种COVID-19疫苗，并根据食品药品监督管理局（FDA）批准的重组带状疱疹疫苗接种HZ疫苗。
Herpes zoster (HZ) has been identified as a potential association with the BNT162b2 COVID-19 vaccination. This study evaluated this possible association in a cohort of patients receiving the vaccination. Epic electronic health records of adult patients who received at least one COVID-19 vaccination between January 12, 2020 and 9/30/2021 within the NYU Langone Health were reviewed to analyze a new diagnosis of herpes zoster within 3 months before compared to 3 months after vaccination. Of the 596,111 patients who received at least one COVID-19 vaccination, 716 patients were diagnosed with HZ within three months prior to vaccination, compared to 781 patients diagnosed within 3 months afterwards. Using the chi-square test for independence of proportions, there was not a statistically significant difference in frequency of HZ before (proportion: 0.0012, 95% CI: [0.0011, 0.0013]) vs. after vaccination (proportion: 0.0013, 95% CI: [0.0012, 0.0014]); (p = 0.093). This study did not find evidence of an association between COVID-19 vaccination and a new diagnosis of HZ. We encourage health care professionals to strongly recommend COVID-19 vaccinations per Centers for Disease Control (CDC) recommendations and vaccination against HZ according to Food and Drug Administration (FDA) approval for the recombinant zoster vaccine.