Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder.
Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder.
复制标题
酸响应双靶点纳米颗粒封装阿司匹林拯救自闭症谱系障碍的免疫激活和表型。
DOI：
10.1002/advs.202104286
复制
发表时间：
2022-05
期刊：
影响因子：
15.1
通讯作者：
Gao, Huile
中科院分区：
文献类型：
--
作者：
He, Xueqin;Xie, Jiang;Zhang, Jing;Wang, Xiaorong;Jia, Xufeng;Yin, Heng;Qiu, Zhongqing;Yang, Zhihang;Chen, Jiao;Ji, Zhiliang;Yu, Wenqi;Chen, Meiwan;Xu, Wenming;Gao, Huile
The treatment of autism spectrum disorder (ASD) is one of the most difficult challenges in neurodevelopmental diseases, because of the unclear pathogenesis research and low brain‐lesion targeting efficiency. Besides, maternal immune activation has been reported as the most mature and widely used model of ASD and aspirin‐triggered lipoxin A4 is a potent anti‐inflammatory mediator being involved in the resolution of neuroinflammation in ASD. Therefore, an aspirin encapsulated cascade drug delivery system (Asp@TMNPs) is established, which can successively target the blood–brain barrier (BBB) and microglial cells and response to the acid microenvironment in lysosome. As a result, the mitochondrial oxidative stress, DNA damage, and inflammation of microglial cells are prominently alleviated. After the treatment of Asp@TMNPs, the social interaction, stereotype behavior, and anxious condition of ASD mice are notably improved and the activation of microglial cells is inhibited. Overall, this system successively penetrates the BBB and targets microglial cells, therefore, it significantly enhances the intracephalic drug accumulation and improves anti‐neuroinflammatory efficacy of aspirin, providing a promising strategy for ASD treatment. An aspirin encapsulated cascade drug delivery system (Asp@TMNPs) is proposed to rescue the immune activation and phenotype in autism spectrum disorder (ASD). In this system, Asp@TMNPs successively penetrate the blood–brain barrier and target microglial cells, and then significantly enhance the intracephalic drug accumulation and improve anti‐neuroinflammatory efficacy of aspirin, providing a promising strategy for ASD treatment.
登录
查看更多内容
纳米清洁剂专门穿透病变处的血脑屏障，清除有毒蛋白质并调节阿尔茨海默病的炎症
DOI：
10.1016/j.apsb.2021.04.022
发表时间：
2021-12
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Lei T;Yang Z;Xia X;Chen Y;Yang X;Xie R;Tong F;Wang X;Gao H
通讯作者：
Gao H
PharmMapper 服务器：使用药效团映射方法识别潜在药物靶标的网络服务器
影响因子：
14.9
作者：
Liu X;Ouyang S;Yu B;Liu Y;Huang K;Gong J;Zheng S;Li Z;Li H;Jiang H
通讯作者：
Jiang H
自闭症谱系障碍。
DOI：
10.1038/s41572-019-0138-4
发表时间：
2020-01-16
期刊：
Nature reviews. Disease primers
影响因子：
--
作者：
Lord C;Brugha TS;Charman T;Cusack J;Dumas G;Frazier T;Jones EJH;Jones RM;Pickles A;State MW;Taylor JL;Veenstra-VanderWeele J
通讯作者：
Veenstra-VanderWeele J
影响因子：
3.9
作者：
Li C;Zhao B;Lin C;Gong Z;An X
通讯作者：
An X
影响因子：
3.6
作者：
Roh JW;Bae S;Kim Y;Son NH;Cho DK;Kim JS;Kim BK;Choi D;Hong MK;Jeong MH;Jang Y;KAMIR-NIH Investigators
通讯作者：
KAMIR-NIH Investigators