GENETIC-POLYMORPHISM OF OROSOMUCOID (ORM) IN POPULATIONS OF THE UNITED-KINGDOM, INDIAN SUBCONTINENT, AND CAMBODIA
GENETIC-POLYMORPHISM OF OROSOMUCOID (ORM) IN POPULATIONS OF THE UNITED-KINGDOM, INDIAN SUBCONTINENT, AND CAMBODIA
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DOI：
10.1007/bf01874139
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发表时间：
1993-09-01
期刊：
影响因子：
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通讯作者：
PAPIHA, SS
中科院分区：
文献类型：
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作者：
MASTANA, SS;JAYASEKARA, R;PAPIHA, SS
通过等电聚焦（IEF）和免疫固定法对来自英国东米德兰兹、印度、斯里兰卡和柬埔寨的15个不同人群的人血清类粘蛋白（ORM）的遗传变异进行了研究。在各种亚洲和英国人群之间观察到统计学显著差异，但亚洲和欧洲人群之间的差异较小。ORM1等位基因在人群中的分布调查到目前为止，提出了一个有趣的东西地理渐变。有一个建议，目前一天广泛的多态性在ORM1基因座可能会受到选择。
The genetic variation of the human serum orosomucoid (ORM) was investigated by isoelectric focusing (IEF) followed by immunofixation in 15 different populations from East Midlands (United Kingdom), India, Sri Lanka, and Cambodia. Statistically significant differences were observed between various Asiatic and British populations, however differences within Asiatic and European populations were minor. The distribution of ORM1 alleles in populations investigated to date suggests an interesting east-west geographical cline. There is a suggestion that present day wide polymorphism at the ORM1 locus may be influenced by selection.