Fabrication of multifunctional ferric oxide nanoparticles for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement
Fabrication of multifunctional ferric oxide nanoparticles for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement
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用于肿瘤靶向磁共振成像和磁场增强精确光热治疗的多功能三氧化二铁纳米颗粒的制备
DOI：
10.1039/c7tb01959a
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发表时间：
2017-11-21
影响因子：
7
通讯作者：
Wang, Zhenxin
中科院分区：
文献类型：
--
作者：
Liu, Jiaxin;Chen, Hongda;Wang, Zhenxin
在这项研究中，使用油包水微乳液方法在油酸覆盖的超顺磁性三氧化二铁纳米颗粒（Fe 2 O3 NP）上涂覆近红外光（NIR）吸收聚多巴胺（PDA）壳，然后与亲和体Z（IGF 1 R：4551）（一种对肿瘤具有高亲和力的肽和聚乙二醇（PEG）稳定剂）偶联，构建了生物相容性纳米治疗诊断平台（称为Fe 2 O3 @PDA-affibody）。Fe 2 O3 @ PDA-MRI主体将T-2加权磁共振成像（MRI）、肿瘤靶向和磁场（MF）增强光热治疗（PTT）功能集成到一体化系统中。Fe 2 O3 @ PDA-binding body在SW 620荷瘤小鼠的MRI中显示出高的负对比度，MRI信号降低了68%，表明Fe 2 O3 @ PDA-binding body能够以高效率和特异性识别肿瘤。此外，在近红外（NIR）（808 nm）激光照射下，借助聚焦于靶向肿瘤的外部MF，实现了高蓄积率（413.5% ID g（-1））和增强的肿瘤生长抑制，从而完全根除了鼠源性SW 620肿瘤，而不会再生长。
In this study, a biocompatible nanotheranostic platform (termed as Fe2O3@PDA-affibody) has been constructed on the basis of coating a near-infrared light (NIR)-absorbing polydopamine (PDA) shell on oleic acid-capped superparamagnetic ferric oxide nanoparticles (Fe2O3 NPs) using the water-in-oil microemulsion method and then conjugated with affibody Z(IGF1R:4551), a peptide with high affinity to tumor and a polyethylene glycol (PEG) stabilizer. The Fe2O3@PDA-affibody integrates T-2-weighted magnetic resonance imaging (MRI), tumor-targeting, and magnetic field (MF)-enhanced photothermal therapy (PTT) functionalities into an all-in-one system. The Fe2O3@PDA-affibody shows high negative contrast in the MRI of an SW620 tumor bearing mouse with a decrease of 68% MRI signal, indicating that the Fe2O3@PDA-affibody can recognize tumor with high efficacy and specificity. Furthermore, a high accumulation ratio (413.5% ID g(-1)) and enhanced inhibition of tumor growth are achieved under near-infrared (NIR) (808 nm) laser irradiation with the aid of an external MF focused on the targeted tumor, resulting in complete eradication of mouse-borne SW620 tumors without regrowth.