Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC study
Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC study
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DOI：
10.1093/aje/kwn069
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发表时间：
2008-06-01
影响因子：
5
通讯作者：
Clavel-Chapelon, Francoise
中科院分区：
文献类型：
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作者：
Chajes, Veronique;Thiebaut, Anne C. M.;Clavel-Chapelon, Francoise
作者在E3 N研究（1989-2002）中评估了血清磷脂脂肪酸（作为脂肪酸摄入量的生物标志物）与女性乳腺癌风险之间的关系，E3 N研究是欧洲癌症和营养前瞻性调查的法国部分。在平均7年的随访中，在19,934名妇女中记录了363例侵袭性乳腺癌的病例，这些妇女在基线（1995-1998年）完成了饮食史问卷并提供了血清样本。对照组按年龄、采血时的绝经状态、采血时的空腹状态、日期和采血中心与病例随机匹配。用气相色谱法测定血清磷脂脂肪酸组成。采用条件logistic回归分析计算了随着脂肪酸水平的增加，乳腺癌风险的校正比值比。乳腺癌风险的增加与反式单不饱和脂肪酸棕榈油酸和反式单不饱和脂肪酸水平的增加有关（最高五分位数与最低五分位数：比值比= 1.75，95%置信区间：1.08，2.83; p趋势= 0.018）。顺式单不饱和脂肪酸与乳腺癌风险无关。高血清反式单不饱和脂肪酸水平，可能反映了工业加工食品的高摄入量，可能是导致女性浸润性乳腺癌风险增加的一个因素。
The authors assessed the association between serum phospholipid fatty acids as biomarkers of fatty acid intake and breast cancer risk among women in the E3N Study (1989-2002), the French component of the European Prospective Investigation into Cancer and Nutrition. During an average of 7 years of follow-up, 363 cases of incident invasive breast cancer were documented among 19,934 women who, at baseline (1995-1998), had completed a diet history questionnaire and provided serum samples. Controls were randomly matched to cases by age, menopausal status at blood collection, fasting status at blood collection, date, and collection center. Serum phospholipid fatty acid composition was assessed by gas chromatography. Adjusted odds ratios for risk of breast cancer with increasing levels of fatty acids were calculated using conditional logistic regression. An increased risk of breast cancer was associated with increasing levels of the trans-monounsaturated fatty acids palmitoleic acid and elaidic acid (highest quintile vs. lowest: odds ratio = 1.75, 95% confidence interval: 1.08, 2.83; p-trend = 0.018). cis-Monounsaturated fatty acids were unrelated to breast cancer risk. A high serum level of trans-monounsaturated fatty acids, presumably reflecting a high intake of industrially processed foods, is probably one factor contributing to increased risk of invasive breast cancer in women.