Differential Effects of E-Cigarette on Microvascular Endothelial Function, Arterial Stiffness and Oxidative Stress: A Randomized Crossover Trial
Differential Effects of E-Cigarette on Microvascular Endothelial Function, Arterial Stiffness and Oxidative Stress: A Randomized Crossover Trial
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DOI：
10.1038/s41598-018-28723-0
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发表时间：
2018-07-10
影响因子：
4.6
通讯作者：
van de Borne, Philippe
中科院分区：
文献类型：
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作者：
Chaumont, Martin;de Becker, Benjamin;van de Borne, Philippe
丙二醇和甘油是允许液体蒸发和尼古丁运输的电子香烟载体。这些不同成分对心血管系统的各自影响尚不清楚。我们评估了媒介物（丙二醇和甘油）和尼古丁对微循环功能、动脉僵硬度、血流动力学参数和氧化应激的不同影响。在一项随机、单盲、3阶段交叉设计研究中，25名吸烟者暴露于含尼古丁和不含尼古丁的电子烟以及假电子烟。在没有尼古丁的情况下，无论是假电子烟还是电子烟都不会导致心血管参数或氧化应激的改变。相比之下，使用尼古丁的电子烟：1）乙酰胆碱介导的血管舒张受损（平均值+/-标准误平均值）（曲线下面积，灌注单位（PU），3385 +/-27 PU至2271 +/-27 PU，p < 0.0001）; 2）动脉硬度指数增加，即针对心律校正的增强指数（-3.5 +/- 1.5%至1.9 +/- 2.3%; p = 0.013）和脉搏波速度（4.9 +/- 0.1 m.s（-1）至5.3 +/- 0（.1）m.s（-1）; p < 0.0001）; 3）收缩压和舒张压以及心率增加（所有p < 0.0001）和最后; 4）升高血浆髓过氧化物酶（中位数[四分位距]）（13.6 ng.ml（-1）[10-17.7]至18.9 ng. ml（-1）[12.2-54.4]，p= 0.005）。我们的研究结果表明，高温电子烟载体蒸发不会改变微血管和大血管功能以及氧化应激，并且这些影响完全归因于尼古丁。
Propylene glycol and glycerol are electronic cigarettes vehicles allowing liquid vaporization and nicotine transport. The respective effects of these different constituents on the cardiovascular system are unknown. We assessed the differential effects of vehicles (propylene glycol and glycerol) and nicotine on microcirculatory function, arterial stiffness, hemodynamic parameters and oxidative stress. Twenty-five tobacco smokers were exposed to vaping with and without nicotine, and sham vaping, in a randomized, single blind, 3-period crossover design study. Neither sham-vaping nor vaping in the absence of nicotine resulted in modifications of cardiovascular parameters or oxidative stress. In contrast, vaping with nicotine: 1) impaired acetylcholine mediated vasodilation (mean +/- standard error mean) (area under curve, perfusion unit (PU), 3385 +/- 27PU to 2271 +/- 27PU, p < 0.0001); 2) increased indices of arterial stiffness, namely augmentation index corrected for heart rhythm (-3.5 +/- 1.5% to 1.9 +/- 2.3%; p = 0.013) and pulse wave velocity (4.9 +/- 0.1 m.s(-1) to 5.3 +/- 0(.1) m.s(-1); p < 0.0001); 3) increased systolic and diastolic blood pressures as well as heart rate (all p < 0.0001) and finally; 4) raised plasma myeloperoxidase (median [interquartile range]) (13.6 ng.ml(-1) [10-17.7] to 18.9 ng.ml(-1) [12.2-54.4], p= 0.005). Our findings demonstrated that high temperature e-cigarette vehicle vaporization does not alter micro- and macrovascular function, and oxidative stress, and that these effects are solely attributable to nicotine.