Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybrid 18F-NaF PET/MRI
Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybrid 18F-NaF PET/MRI
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DOI：
10.1007/s12350-020-02400-0
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发表时间：
2020-11-03
影响因子：
2.4
通讯作者：
Nighoghossian, Norbert
中科院分区：
文献类型：
--
作者：
Mechtouff, Laura;Sigovan, Monica;Nighoghossian, Norbert
背景 先前的研究表明微钙化在斑块脆弱性中的作用。这项探索性研究旨在评估混合正电子发射断层扫描 (PET)/磁共振成像 (MRI) 使用 F-18-氟化钠 (F-18-NaF) 同时检查 F-18-NaF 摄取、微钙化标志物和脆弱性形态标准的潜力。方法和结果 我们纳入了 12 名近期有症状或无症状颈动脉狭窄的患者。所有患者均接受 F-18-NaF PET/MRI 检查。在罪魁祸首和非罪魁祸首（包括有症状患者的对侧斑块）斑块以及其他动脉壁中测量 F-18-NaF 目标与背景比 (TBR)。通过 MRI 评估脆弱性的形态学标准。还收集了矿物质代谢标记物。与非罪犯斑块相比，罪犯斑块中的 F-18-NaF 摄取量较高（中位 TBR 2.6 [2.2-2.8] vs 1.7 [1.3-2.2]；P = 0.03），但与 MRI 上易损性的形态学标准无关。我们发现 F-18-NaF 摄取与钙斑体积和比例之间存在正相关，但与循环组织非特异性碱性磷酸酶 (TNAP) 活性和无机焦磷酸盐 (PPi) 水平不存在正相关。其他动脉壁中的 F-18-NaF 摄取在有症状和无症状患者之间没有差异。结论 F-18-NaF PET/MRI 可能是一种很有前途的工具，可以为斑块脆弱性提供更多见解。
Background Previous studies have suggested the role of microcalcifications in plaque vulnerability. This exploratory study sought to assess the potential of hybrid positron-emission tomography (PET)/magnetic resonance imaging (MRI) using F-18-sodium fluoride (F-18-NaF) to check simultaneously F-18-NaF uptake, a marker of microcalcifications, and morphological criteria of vulnerability. Methods and results We included 12 patients with either recently symptomatic or asymptomatic carotid stenosis. All patients underwent F-18-NaF PET/MRI. F-18-NaF target-to-background ratio (TBR) was measured in culprit and nonculprit (including contralateral plaques of symptomatic patients) plaques as well as in other arterial walls. Morphological criteria of vulnerability were assessed on MRI. Mineral metabolism markers were also collected. F-18-NaF uptake was higher in culprit compared to nonculprit plaques (median TBR 2.6 [2.2-2.8] vs 1.7 [1.3-2.2]; P = 0.03) but was not associated with morphological criteria of vulnerability on MRI. We found a positive correlation between F-18-NaF uptake and calcium plaque volume and ratio but not with circulating tissue-nonspecific alkaline phosphatase (TNAP) activity and inorganic pyrophosphate (PPi) levels. F-18-NaF uptake in the other arterial walls did not differ between symptomatic and asymptomatic patients. Conclusions F-18-NaF PET/MRI may be a promising tool for providing additional insights into the plaque vulnerability.