Comparison of the standard gamble, rating scale, AQLQ and SF-36 for measuring quality of life in asthma
Comparison of the standard gamble, rating scale, AQLQ and SF-36 for measuring quality of life in asthma
复制标题
DOI：
10.1183/09031936.01.00088301
复制
发表时间：
2001-07-01
影响因子：
24.3
通讯作者：
Roberts, JN
中科院分区：
文献类型：
--
作者：
Juniper, EF;Norman, GR;Roberts, JN
随着人们对健康经济学的兴趣日益增长，人们需要一种有效的方法来测量哮喘患者的健康相关生活质量（HRQL）。本研究的目的是开发疾病特异性版本的标准赌博和评级量表，比较其测量特性与哮喘生活质量问卷（AQLQ）和医学结局调查简表36（SF-36），以及确定其有效性评估哮喘特异性生活质量。参与者在基线和1、5和9周后完成标准赌博、评定量表、AQLQ、SF-36和其他临床哮喘状态的测量。在评估之间哮喘稳定的患者中，评定量表的可靠性良好（组内相关系数（ICC）=0.89）和AQLQ（ICC=0.95），但SF-36精神评分（ICC=0.68）、SF-36身体评分（ICC= 0.65）和标准赌博评分（ICC=0.59）更为适度。反应性指数以AQLQ最高（1.35），其次是评定量表（0.74）、SF-36的身体评分（0.61）和标准赌博（0.31）。结构效度（与健康状况的其他指标的相关性）是最强的AQLQ和等级量表。生活质量问卷对哮喘患者的生活质量有较强的测量特性，而健康调查简表36的躯体总分具有更适中的测量特性。虽然疾病特异性标准赌博具有可接受的判别性质，但其评价性质太不充分，不能用于成本/效用分析。标准赌博和评级量表之间的相关性较差，表明效用不能从评级量表数据中得出。
With interest in health economics growing, there is a demand for valid methods for measuring health-related quality of life (HRQL) in asthma using utilities. The aims of this study were to develop disease-specific versions of the standard gamble and rating scale, to compare their measurement properties with those of the Asthma Quality of Life Questionnaire (AQLQ) and the Medical Outcomes Survey Short-Form 36 (SF-36), as well as to determine their validity for assessing asthma-specific quality of life.Forty adults with symptomatic asthma participated in a 9-week observational study. Participants completed the standard gamble, rating scale, AQLQ, SF-36 and other measures of clinical asthma status at baseline and after 1, 5 and 9 weeks.In patients whose asthma was stable between assessments, reliability was good for the rating scale (intraclass correlation coefficient (ICC)=0.89) and the AQLQ (ICC=0.95) but more modest for the SF-36 mental score (ICC=0.68), SF-36 physical score (ICC= 0.65) and standard gamble (ICC=0.59). The responsiveness index was highest in the AQLQ (1.35), followed by the rating scale (0.74), the physical score of the SF-36 (0.61) and the standard gamble (0.31). Construct validity (correlation with other indices of health status) was strongest for the AQLQ and the rating scale.In conclusion, both the disease-specific rating scale and the Asthma Quality of. Life Questionnaire have strong measurement properties for measuring asthma-specific quality of life, the Short-Form 36 health survey physical summary score has more modest properties. Although the disease-specific standard gamble has acceptable discriminative properties, its evaluative properties are too inadequate for it to be used in cost/utility analyses. Poor correlation between the standard gamble and the rating scale indicates that utilities cannot be derived from rating scale data.