AN EFFICIENT, ONE-POT SYNTHESIS OF 2-DEOXY-2-[F-18]FLUOROACETAMIDO-D-GLUCOPYRANOSE (N-[F-18]FLUOROACETYL-D-GLUCOSAMINE), POTENTIAL DIAGNOSTIC-IMAGING AGENT
AN EFFICIENT, ONE-POT SYNTHESIS OF 2-DEOXY-2-[F-18]FLUOROACETAMIDO-D-GLUCOPYRANOSE (N-[F-18]FLUOROACETYL-D-GLUCOSAMINE), POTENTIAL DIAGNOSTIC-IMAGING AGENT
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DOI：
10.1002/jlcr.2580271111
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发表时间：
1989-11-01
影响因子：
1.8
通讯作者：
SATO, T
中科院分区：
文献类型：
--
作者：
TADA, M;OIKAWA, A;SATO, T
描述了从[18F]氟化物和溴乙酸乙酯开始快速一锅合成2-脱氧-2-[18F]氟乙酰胺-D-吡喃葡萄糖（N-[18F]氟乙酰基-D-葡萄糖胺）(1)。该合成是通过卤素交换、碱性水解和缩合的组合完成的。 [18F] 氟化物是通过使用回旋加速器的 18o (p,n) 18F 核反应产生的。 (1) 的总合成时间、放射化学收率和纯度约为。约 90 分钟Sugar (1) 分别显示出诊断肿瘤成像活性，分别为 9.1% 和 >98%。
A rapid, one-pot synthesis of 2-deoxy-2-[18F]fluoroacetamide-D-glucopyranose (N-[18F]fluoracetyl-D-glucosamine) (1) starting from [18F] fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation. [18F] Fluoride was produced by the 18o (p,n) 18F nuclear reaction using the cyclotron. The total synthesis time, the radiochemical yield, and purity of (1) are ca. 90 min, ca. 9.1%, and >98%, respectively, Sugar (1) showed the diagnostic tumor-imaging activity.