The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients
The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients
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DOI：
10.1016/j.ajog.2011.07.037
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发表时间：
2012-01-01
影响因子：
9.8
通讯作者：
Stepan, Holger
中科院分区：
文献类型：
--
作者：
Verlohren, Stefan;Herraiz, Ignacio;Stepan, Holger
目的：可溶性fms样酪氨酸激酶（sFlt-1）/胎盘生长因子（PlGF）比值是评估先兆子痫的可靠工具。我们检验了sFlt-1/PlGF比率能够识别临产风险的女性的假设。我们的特点是sFlt 1/PlGF比例在不同类型的高血压妊娠disorders.Study设计：我们调查了388单胎妊娠正常妊娠结局，164与PE，36与妊娠期高血压，42与慢性高血压。结果：子痫前期患者血清sFlt-1/PlGF比值显著高于正常对照组及妊娠期高血压患者< 34 weeks and >（P
OBJECTIVE: The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt1/PlGF ratio in different types of hypertensive pregnancy disorders.STUDY DESIGN: We investigated 388 singleton pregnancies with normal pregnancy outcome, 164 with PE, 36 with gestational hypertension, and 42 with chronic hypertension. sFlt-1 and PlGF were measured in serum samples.RESULTS: Patients with preeclampsia had a significantly increased sFlt-1/PlGF ratio as compared with controls and with patients with chronic and gestational hypertension in < 34 weeks and >= 34 weeks (P