The Regulation of Aging and Longevity: A New and Complex Role of p53.
The Regulation of Aging and Longevity: A New and Complex Role of p53.
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DOI：
10.1177/1947601911410223
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发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Wu, Rui
中科院分区：
文献类型：
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作者：
Feng, Zhaohui;Lin, Meihua;Wu, Rui
p53在肿瘤抑制中起着关键作用。作为一种转录因子，p53在响应应激信号时调节其靶基因并启动应激反应，包括细胞周期阻滞、细胞凋亡和/或衰老，从而在肿瘤抑制中发挥其功能。新出现的证据表明，p53在蠕虫、果蝇、小鼠和人类的衰老和长寿调节中也是一个重要但复杂的参与者。在某些情况下，p53会加速衰老进程并缩短寿命，而在其他一些情况下，p53也可以延长寿命。因此，p53似乎以一种依赖于环境的方式调节衰老和长寿。在此，作者回顾了在无脊椎动物和脊椎动物模型中p53在衰老和长寿调节作用研究方面的一些最新进展。此外，他们还讨论了p53调节衰老和长寿的潜在机制，包括p53对胰岛素/TOR信号通路、干细胞/祖细胞以及活性氧的调节。
p53 plays a critical role in tumor suppression. As a transcription factor, in response to stress signals, p53 regulates its target genes and initiates stress responses, including cell cycle arrest, apoptosis, and/or senescence, to exert its function in tumor suppression. Emerging evidence has suggested that p53 is also an important but complex player in the regulation of aging and longevity in worms, flies, mice, and humans. Whereas p53 accelerates the aging process and shortens life span in some contexts, p53 can also extend life span in some other contexts. Thus, p53 appears to regulate aging and longevity in a context-dependent manner. Here, the authors review some recent advances in the study of the role of p53 in the regulation of aging and longevity in both invertebrate and vertebrate models. Furthermore, they discuss the potential mechanisms by which p53 regulates aging and longevity, including the p53 regulation of insulin/TOR signaling, stem/progenitor cells, and reactive oxygen species.