Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer
Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer
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DOI：
10.1016/j.biopha.2016.01.025
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发表时间：
2016-03-01
影响因子：
7.5
通讯作者：
Shu, Yongqian
中科院分区：
文献类型：
--
作者：
Ma, Pei;Xu, Tongpeng;Shu, Yongqian
长链非编码RNA（lncRNA）作为生物标志物和在癌症的生物学过程和肿瘤发生中的重要调节剂而出现。PANDAR（CDKN1A反义DNA损伤激活RNA的启动子）作为生物标志物，参与多种癌症的发展。然而，PANDAR在胃癌中的临床应用价值尚不清楚。因此，我们开展了本研究，旨在确定PANDAR在胃癌患者中的临床意义。我们使用定量实时PCR分析了100对胃癌组织中PANDAR的表达水平。我们的研究结果表明，PANDAR在胃癌组织中的表达与配对的癌旁正常组织相比显著增加。PANDAR的高表达与肿瘤浸润深度、TNM分期及淋巴结转移有关。重要的是，PANDAR的高表达可以作为胃癌中独立的不利预后作用。总之，PANDAR可能是一个潜在的新的生物标志物，预测胃癌的预后。(C)2016 Elsevier Masson SAS。All rights reserved.
Long non-coding RNAs (lncRNAs) are emerging as biomarkers and as important regulators in biological processes and tumorigenesis in cancer. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) serves as biomarkers and involves in development of multiple cancers. However, its clinical value of PANDAR in gastric cancer is still unknown. Hence, we carried out the present study aiming to identify the clinical significance of PANDAR in gastric cancer patients. We analyzed the expression levels of PANDAR in 100 paired gastric cancer tissues using Quantitative Real-time PCR. Our results showed that the expression of PANDAR was significantly increased in gastric cancer tissues compared with paired adjacent normal tissues. Furthermore, high expression of PANDAR was correlated with depth of invasion, TNM stage and lymphatic metastasis. Importantly, high expression of PANDAR could serve as an independent unfavorable prognostic role in gastric cancer. In conclusion, PANDAR may be a potential novel biomarker that predicts prognosis in gastric cancer. (C) 2016 Elsevier Masson SAS. All rights reserved.