Maternal ambient air pollution exposure with spatial-temporal variations and preterm birth risk assessment during 2013-2017 in Zhejiang Province, China
Maternal ambient air pollution exposure with spatial-temporal variations and preterm birth risk assessment during 2013-2017 in Zhejiang Province, China
复制标题
2013-2017年浙江省孕产妇环境空气污染暴露时空变化及早产风险评估
DOI：
10.1016/j.envint.2019.105242
复制
发表时间：
2019-12-01
影响因子：
11.8
通讯作者：
Zhao, Meirong
中科院分区：
文献类型：
--
作者：
Sun, Zhe;Yang, Liyang;Zhao, Meirong
早产（PTB）可引起显著的新生儿发病率和死亡率，以及儿童的长期健康缺陷。许多研究表明，妊娠期接触环境空气污染与患肺结核风险之间存在关联，但大多数研究只关注一种空气污染物，如PM2.5。在这项基于人群的环境流行病学研究中，我们在中国浙江省招募了6275名孕妇，并评估了她们在2013-2017年期间对各种空气污染物的妊娠暴露情况。在调整所有混杂因素后，使用时间-事件逻辑回归来估计风险关联，并使用准aqi模型和PCA-GLM分析来解决多污染物回归模型中的共线性问题。结果发现，妊娠期暴露于环境空气污染物与PTB的发生显著相关，其中SO2是最大的贡献者，占29.4%。主成分分析结果显示，主要因子（PM2.5、PM10、SO2和NO2的组合）、碳因子（CO）和臭氧因子（O-3）对PTB风险的贡献率分别为63.4%、17.1%和19.5%。孕早期和晚期是最关键的暴露窗口，这表明孕妇在这些敏感时期最好避免接触严重的空气污染。
Preterm birth (PTB) can give rise to significant neonatal morbidity and mortality, as well as children's long-term health defects. Many studies have illustrated the associations between ambient air pollution exposure during gestational periods and PTB risks, but most of them only focused on one single air pollutant, such as PM2.5. In this population-based environmental-epidemiology study, we recruited 6275 pregnant mothers in Zhejiang Province, China, and evaluated their gestational exposures to various air pollutants during 2013-2017. Time-to-event logistic regressions were performed to estimate risk associations after adjusting all confounders, and Quasi-AQI model and PCA-GLM analysis were applied to resolve the collinearity issues in multi-pollutant regression models. It was found that gestational exposure to ambient air pollutants was significantly associated with the occurrence of PTB, and SO2 was the largest contributor with a proportion of 29.4%. Three new variables, prime factor (a combination of PM2.5, PM10, SO2, and NO2), carbon factor (CO), and ozone factor (O-3), were generated by PCA integration, contributing 63.4%, 17.1%, and 19.5% to PTB risks, respectively. The first and third trimester was the most crucial exposure window, suggesting the pregnant mothers better to avoid severe air pollution exposures during these sensitive periods.