Cutting edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease
Cutting edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease
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DOI：
10.4049/jimmunol.168.1.9
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发表时间：
2002-01-01
影响因子：
4.4
通讯作者：
Tsubata, T
中科院分区：
文献类型：
--
作者：
Higuchi, T;Aiba, Y;Tsubata, T
CD40配体（CD40 L）异位表达于系统性红斑狼疮（SLE）患者和狼疮易感BXSB小鼠的B细胞上。为了评估异位表达的CD 40 L在SLE发展中的作用，我们建立了在B细胞上表达CD 40 L的转基因小鼠。一些12至14月龄的CD40L转基因小鼠自发产生自身抗体，如抗核抗体、抗DNA抗体和抗组蛋白抗体。此外，大约一半的转基因小鼠发生肾小球肾炎与免疫复合物沉积，而正常的同窝仔的肾脏没有表现出任何病理结果或只有轻微的组织学变化。这些结果表明，B细胞上的CD 40 L在未知的环境因素存在下引起狼疮样疾病，这些环境因素本身不会诱导疾病。因此，B细胞异位表达CD40 L可能在SLE的发生发展中起重要作用。
CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice. To assess the role of the ectopic CD40L expression in development of SLE, we have established transgenic mice expressing CD40L on B cells. Some of the 12- to 14-mo-old CD40L-transgenic mice spontaneously produced autoantibodies such as antinuclear Abs, anti-DNA Abs, and antihistone Abs. Moreover, approximately half of the transgenic mice developed glomerulonephritis with immune-complex deposition, whereas the kidneys of the normal littermates showed either no pathological findings or only mild histological changes. These results indicate that CD40L on B cells causes lupus-like disease in the presence of yet unknown environmental factors that by themselves do not induce the disease. Thus, ectopic CD40L expression on B cells may play a crucial role in development of SLE.