The Relationships between Adverse Events, Early Antecedents, and Carbon Dioxide Reactivity as an Intermediate Phenotype of Panic Disorder A General Population Study
The Relationships between Adverse Events, Early Antecedents, and Carbon Dioxide Reactivity as an Intermediate Phenotype of Panic Disorder A General Population Study
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DOI：
10.1159/000259417
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发表时间：
2010-01-01
影响因子：
22.8
通讯作者：
Battaglia, Marco
中科院分区：
文献类型：
--
作者：
Ogliari, Anna;Tambs, Kristian;Battaglia, Marco
背景：虽然不良事件一直被描述为先于恐慌症发作并可能引发恐慌症发作，但没有关于它们改变个体对吸入二氧化碳的反应能力的信息，吸入二氧化碳是恐慌症易感性的假定中间表型。方法：挪威公共卫生研究所双胞胎小组的 712 名受试者接受了 35% CO2/65% O-2 吸入挑战测试和基于访谈的 DSM-IV 恐慌症、分离焦虑症、童年父母分离/失去、重大生活事件、窒息性不良事件和常见压力生活事件的终生评估。应用回归模型来预测吸入 35% CO2/65% O-2 后的总体主观焦虑和 DSM-IV 恐慌症状。结果：对作为半连续变量测量的挑战的反应是通过童年分离焦虑、童年失去父母、常见压力事件、主要生活事件、窒息事件和女性的症状来预测的。在从分析中排除终生惊恐发作/障碍的受试者后，大多数这些预测因素的作用得到证实并保持正确。结论：之前的临床研究报告了一些影响个体对惊恐障碍的易感性的因素，这些因素似乎也影响了一般人群对吸入二氧化碳的个体反应性。某些风险因素可能会同时影响个人对恐慌的敏感性和对高碳酸血症的过度敏感性。版权所有 (C) 2009 S. Karger AG，巴塞尔
Background: Although adverse events have been consistently described to precede and potentially precipitate the onset of panic disorder, there is no information about their ability to alter the individual reactivity to inhaled carbon dioxide, a putative intermediate phenotype of susceptibility to panic disorder. Method: Seven-hundred twelve subjects belonging to the general population-based Norwegian Institute of Public Health Twin Panel underwent a 35% CO2/65% O-2 inhalation challenge test and interview-based lifetime assessments of DSM-IV panic disorder, separation anxiety disorder, childhood parental separation/loss, major life events, adverse events of suffocative nature and common stressful life events. Regression models were applied to predict global subjective anxiety and DSM-IV panic symptoms after 35% CO2/65% O-2 inhalation. Results: The responses to the challenge measured as semicontinuous variables were predicted by symptoms of childhood separation anxiety, childhood parental loss, common stressful events, major life events, suffocative events and the female gender. The role of most of these predictors was confirmed and held true after the exclusion of subjects with lifetime panic attacks/disorder from the analyses. Conclusions: Several factors which have been reported by previous clinical studies to influence the individual susceptibility to develop panic disorder seem to affect the individual reactivity to inhaled carbon dioxide in people from the general population. Some elements of risk may impact simultaneously upon the individual liability to panic and exaggerated sensitivity to hypercapnia. Copyright (C) 2009 S. Karger AG, Basel