Age Differences in Prefrontal Surface Area and Thickness in Middle Aged to Older Adults.
Age Differences in Prefrontal Surface Area and Thickness in Middle Aged to Older Adults.
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DOI：
10.3389/fnagi.2015.00250
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发表时间：
2015
影响因子：
4.8
通讯作者：
Woods AJ
中科院分区：
文献类型：
--
作者：
Dotson VM;Szymkowicz SM;Sozda CN;Kirton JW;Green ML;O'Shea A;McLaren ME;Anton SD;Manini TM;Woods AJ
年龄与表面积和皮质厚度的减少有关，特别是在前额叶区域。也有证据表明，在某些地区，老年人的厚度更大。一些研究中的非线性年龄效应表明，年龄可能会在以后的几十年中继续影响大脑结构，但相对较少的研究已经研究了年龄对中年人大脑结构的影响。我们调查了年龄在51岁和81岁之间的健康成年人的前额叶表面积和皮质厚度的年龄差异。参与者接受了结构3特斯拉磁共振成像扫描。基于先验假设，主要分析集中在背外侧前额叶皮层、前扣带回皮层和眶额皮层的表面积和皮层厚度。我们还对整个皮质的表面积和皮质厚度进行了探索性顶点分析。我们发现，年龄越大，背外侧前额叶和眶额皮质的表面积越小，但背外侧前额叶和前扣带皮质的皮质厚度越大。顶点分析显示较小的表面积，主要是额叶区域在老年人，但没有年龄的影响，发现皮质厚度。结果表明，年龄与减少的表面积，但更大的皮质厚度在前额叶区域在以后的几十年的生活，并强调了不同的影响年龄对区域表面积和皮质厚度。
Age is associated with reductions in surface area and cortical thickness, particularly in prefrontal regions. There is also evidence of greater thickness in some regions at older ages. Non-linear age effects in some studies suggest that age may continue to impact brain structure in later decades of life, but relatively few studies have examined the impact of age on brain structure within middle-aged to older adults. We investigated age differences in prefrontal surface area and cortical thickness in healthy adults between the ages of 51 and 81 years. Participants received a structural 3-Tesla magnetic resonance imaging scan. Based on a priori hypotheses, primary analyses focused on surface area and cortical thickness in the dorsolateral prefrontal cortex, anterior cingulate cortex, and orbitofrontal cortex. We also performed exploratory vertex-wise analyses of surface area and cortical thickness across the entire cortex. We found that older age was associated with smaller surface area in the dorsolateral prefrontal and orbitofrontal cortices but greater cortical thickness in the dorsolateral prefrontal and anterior cingulate cortices. Vertex-wise analyses revealed smaller surface area in primarily frontal regions at older ages, but no age effects were found for cortical thickness. Results suggest age is associated with reduced surface area but greater cortical thickness in prefrontal regions during later decades of life, and highlight the differential effects age has on regional surface area and cortical thickness.