Safety and tolerability of N-Acetylcysteine in cocaine-dependent individuals
Safety and tolerability of N-Acetylcysteine in cocaine-dependent individuals
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DOI：
10.1080/10550490500419169
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发表时间：
2006-01-01
影响因子：
3.7
通讯作者：
Brady, K
中科院分区：
文献类型：
--
作者：
LaRowe, SD;Mardikian, P;Brady, K
进行了一项双盲安慰剂对照交叉I期试验，以评估n -乙酰半胱氨酸（NAC）在健康可卡因依赖人群中的安全性和耐受性。13名参与者参加了为期三天的住院治疗，在此期间他们接受了安慰剂或NAC。在接下来一周的第二次三天住院期间，受试者被交叉接受相反的药物治疗。在安慰剂和NAC条件下，只有轻微的副作用被注意到，并且报告副作用的受试者数量没有差异。在NAC条件下，戒断症状和渴望有更大的减少趋势。这些初步结果表明，NAC在健康的可卡因依赖个体中耐受性良好，并可能减少可卡因相关戒断症状和渴望。
A double-blind placebo-controlled crossover Phase I trial was conducted to assess the safety and tolerability of N-Acetylcysteine (NAC) in healthy, cocaine-dependent humans. Thirteen participants attended a three-day hospitalization in which they received placebo or NAC. Subjects were crossed over to receive the opposite medication condition during a second three-day hospitalization, which occurred the following week. Across placebo and NAC conditions, only mild side effects were noted, and the number of subjects reporting side effects did not differ. There were trends for a greater reduction in withdrawal symptoms and craving within the NAC condition. These preliminary results suggest that NAC is well tolerated in healthy, cocaine-dependent individuals and may reduce cocaine-related withdrawal symptoms and craving.