[Early case of idiopathic pulmonary alveolar proteinosis positive for serum anti-GM-CSF antibody].
[Early case of idiopathic pulmonary alveolar proteinosis positive for serum anti-GM-CSF antibody].
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血清抗GM-CSF抗体阳性早期特发性肺泡蛋白沉积症病例[J].
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
M. Kido
中科院分区：
文献类型：
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作者：
K. Yamasaki;C. Yoshii;Chinatsu Nishida;M. Kunimoto;Fumiyoshi Yoda;Toshinori Kawanami;Y. Sakurai;Takehiro Nakamura;K. Yatera;M. Kido
一位56岁的无症状女性，从不吸烟，身体健康，因体检时胸部X光片上出现异常阴影而入院。胸部CT显示右上肺野磨玻璃影。在此之前，在任何一次年度体检中，胸部X光检查都没有发现异常。由于纤维支气管镜检查（BAL和TBLB）无法显示任何诊断信息，因此进行了VATS活检。组织学检查显示肺泡腔内充满PAS阳性颗粒物质，电镜下可见融合膜结构和无定形物质。血清抗GM-CSF抗体阳性（7.908 μ g/ml）。基于这些发现，我们认为这是特发性肺泡蛋白沉积症的早期病例。
An asymptomatic 56-year-old woman who had never smoked and had been healthy was admitted to our hospital because of abnormal shadows on a chest X-ray film taken on a medical check-up. Chest CT showed ground-glass opacities in the right upper lung field. No abnormality on chest X-ray had been pointed out on any annual medical check up until then. As bronchofiberscopy (BAL and TBLB) could not reveal any diagnostic information, VATS biopsy was performed. Histological findings showed that alveolar spaces were filled with PAS-positive granular materials, and fused membrane structures and amorphous material were demonstrated by electron microscopy. Anti-GM-CSF antibody of serum was also positive (7.908 microg/ml). Based on these findings, we decided this was an early case of idiopathic pulmonary alveolar proteinosis.