CORTICAL ACETYLCHOLINE-RELEASE IS INCREASED AND GAMMA-AMINOBUTYRIC-ACID OUTFLOW IS REDUCED DURING MORPHINE-WITHDRAWAL
CORTICAL ACETYLCHOLINE-RELEASE IS INCREASED AND GAMMA-AMINOBUTYRIC-ACID OUTFLOW IS REDUCED DURING MORPHINE-WITHDRAWAL
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DOI：
10.1111/j.1476-5381.1986.tb11191.x
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发表时间：
1986-12-01
影响因子：
7.3
通讯作者：
TANGANELLI, S
中科院分区：
文献类型：
--
作者：
ANTONELLI, T;BEANI, L;TANGANELLI, S
The effects of naloxone on acetylcholine (ACh) and .gamma.-aminobutyric acid (GABA) outflow from the cerebral cortex of freely moving, morphine-dependent guinea-pigs was studied. The cortical efflux of ACh in chronically-treated guinea-pigs was about half of that of normal animals. GABA efflux was unaffected. During opioid withdrawal precipitated by naloxone (0.1-10 mg kg-1, i.p.) the guinea-pigs showed jumping, hyperactivity and wet dog shakes, the intensity of which was directly related to the dose of naloxone. The withdrawal syndrome was accompanied by a dose-dependent increase in ACh release and reduction in GABA outflow; ACh release was increased by naloxone at doses lower (0.1-3 mg kg-1) than those acting on GABA efflux (1-10 mg kg-1). Atropine (10 mg kg-1) and diazepam (5 mg kg-1) did not prevent GABA and ACh changes.
