Dissociating linguistic processes in the left inferior frontal cortex with transcranial magnetic stimulation
Dissociating linguistic processes in the left inferior frontal cortex with transcranial magnetic stimulation
复制标题
DOI：
10.1523/jneurosci.2307-05.2005
复制
发表时间：
2005-08-31
影响因子：
5.3
通讯作者：
Devlin, JT
中科院分区：
文献类型：
--
作者：
Gough, PM;Nobre, AC;Devlin, JT
左下额叶皮层（LIFC）是一个单一的功能区域，还是可以细分为不同的区域，对文字处理有不同的贡献？在这里，我们使用经颅磁刺激（TMS），以调查前和后LIFC时的意义和声音的话正在处理。相对于没有刺激，当参与者专注于同时呈现的单词的含义时，前LIFC的TMS选择性地增加了反应延迟（即，同义词判断），但当他们关注单词的声音模式时（即，同音判断）。相反，相反的解离观察后LIFC，刺激选择性地干扰语音，但不是语义任务。这种双重分离显示了LIFC功能上不同的细分，可以理解为可分离的皮质连接，将前部LIFC连接到与语义记忆相关的颞极区域，将后部LIFC连接到参与听觉语音处理的颞顶区域。
Is the left inferior frontal cortex (LIFC) a single functional region, or can it be subdivided into distinct areas that contribute differently to word processing? Here we used transcranial magnetic stimulation ( TMS) to investigate anterior and posterior LIFC when the meaning and sound of words were being processed. Relative to no stimulation, TMS of the anterior LIFC selectively increased response latencies when participants focused on the meaning of simultaneously presented words (i.e., synonym judgments) but not when they focused on the sound pattern of the words (i.e., homophone judgments). In contrast, the opposite dissociation was observed in the posterior LIFC, where stimulation selectively interfered with the phonological but not the semantic task. This double dissociation shows functionally distinct subdivisions of the LIFC that can be understood in terms of separable corticocortical connections linking the anterior LIFC to temporal pole regions associated with semantic memory and the posterior LIFC to temporoparietal regions involved in auditory speech processing.