Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?
Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?
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DOI：
10.2217/fmb.10.112
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发表时间：
2010-10
影响因子：
3.1
通讯作者：
Braunstein M
中科院分区：
文献类型：
--
作者：
Feltcher ME;Sullivan JT;Braunstein M
蛋白质输出在所有细菌中都是必不可少的，许多细菌病原体依赖于专门的蛋白质输出系统来实现毒力。在结核病的病原体结核分枝杆菌中，保守的总分泌物(SEC)和双精氨酸转位(TAT)途径执行大部分蛋白质输出，两者都是必不可少的。结核分枝杆菌也有专门的出口途径来运输特定的蛋白质亚群。其中一个途径是辅助SecA2系统，它对结核分枝杆菌的毒力非常重要。还有专门的ESX输出系统，在毒力(ESX-1)或基本生理过程(ESX-3)中发挥作用。耐药结核分枝杆菌菌株的日益流行使得开发治疗结核病的新药成为当务之急。在这篇文章中，我们讨论了我们目前对结核分枝杆菌蛋白输出系统的理解，并认为这些途径有可能成为结核病药物的新靶点。
Protein export is essential in all bacteria and many bacterial pathogens depend on specialized protein export systems for virulence. In Mycobacterium tuberculosis, the etiological agent of the disease tuberculosis, the conserved general secretion (Sec) and twin-arginine translocation (Tat) pathways perform the bulk of protein export and are both essential. M. tuberculosis also has specialized export pathways that transport specific subsets of proteins. One such pathway is the accessory SecA2 system, which is important for M. tuberculosis virulence. There are also specialized ESX export systems that function in virulence (ESX-1) or essential physiologic processes (ESX-3). The increasing prevalence of drug-resistant M. tuberculosis strains makes the development of novel drugs for tuberculosis an urgent priority. In this article, we discuss our current understanding of the protein export systems of M. tuberculosis and consider the potential of these pathways to be novel targets for tuberculosis drugs.
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