Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson's disease.
Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson's disease.
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DOI：
10.1038/s41598-017-04254-y
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发表时间：
2017-06-28
影响因子：
4.6
通讯作者：
Foffani G
中科院分区：
文献类型：
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作者：
Dileone M;Carrasco-López MC;Segundo-Rodriguez JC;Mordillo-Mateos L;López-Ariztegui N;Alonso-Frech F;Catalan-Alonso MJ;Obeso JA;Oliviero A;Foffani G
经颅静态磁场刺激（tSMS）是一种最新的低成本非侵入性脑刺激技术，可降低健康受试者的皮质兴奋性。本研究的目的是测试 tSMS 调节帕金森病患者皮质兴奋性的能力。我们进行了一项随机双盲假对照交叉研究，以评估对帕金森病患者受影响更严重的运动皮层进行 10 分钟 tSMS（或假手术）之前和之后的皮质兴奋性。皮层兴奋性通过单脉冲经颅磁刺激 (TMS) 引起的运动诱发电位 (MEP) 的幅度进行量化。 tSMS 显着降低了未用药（多巴胺能药物过夜停药后）患者的 MEP 振幅，但未用药（急性剂量左旋多巴后）。 tSMS 引起的变化的患者之间的变异性明显大于 ON 药物治疗。 ON 药物的变异性可以部分地用疾病进展来解释，即患者越晚期，就越有可能观察到从抑制性 tSMS 可塑性 OFF 药物到矛盾的促进可塑性 ON 药物的转变。这些结果表明，tSMS 会引起帕金森病患者皮质兴奋性的多巴胺依赖性变化。
Transcranial static magnetic field stimulation (tSMS) is a recent low-cost non-invasive brain stimulation technique that decreases cortical excitability in healthy subjects. The objective of the present study was to test the ability of tSMS to modulate cortical excitability in patients with Parkinson’s disease. We performed a randomized double-blind sham-controlled cross-over study to assess cortical excitability before and immediately after tSMS (or sham) applied for 10 min to the more affected motor cortex of patients with Parkinson’s disease. Cortical excitability was quantified by the amplitude of motor evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS). tSMS significantly decreased MEP amplitudes in patients OFF medication (after overnight withdrawal of dopaminergic drugs), but not ON medication (after an acute dose of levodopa). The between-patients variability of tSMS-induced changes was significantly greater ON medication. The variability ON medication could be partly explained by disease progression, i.e. the more advanced the patient, the more likely it was to observe a switch from inhibitory tSMS plasticity OFF medication to paradoxical facilitatory plasticity ON medication. These results suggest that tSMS induces dopamine-dependent changes of cortical excitability in patients with Parkinson’s disease.