A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis
A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis
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DOI：
10.1111/j.1399-3038.2010.01124.x
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发表时间：
2011-06-01
影响因子：
4.4
通讯作者：
Celedon, Juan C.
中科院分区：
文献类型：
--
作者：
Bunyavanich, Supinda;Shargorodsky, Josef;Celedon, Juan C.
P>；过敏性鼻炎(AR)有显著的遗传因素。已经进行了AR的遗传关联研究，但不同的结果使破译特定变异的总体潜在影响具有挑战性。Th2途径在AR的免疫学发展中起着重要作用。我们对Th2途径基因变异与AR的遗传关联性进行了荟萃分析。应用双抽提法检索PubMed和Phenopedia，对Th2途径相关基因多态性及其与AR的关系进行初步研究。用符合我们预定选择标准的数据对每个基因多态进行荟萃分析。分析使用固定和随机效应模型，并根据年龄组、种族和AR定义适当地进行分层。对异质性和发表偏倚进行评估。6项独立研究分析了3个候选多态，共涉及1596个病例和2892个对照，符合我们的纳入标准。总体而言，IL13单核苷酸多态rs20541的A等位基因与AR发病相关(固定效应模型中95%可信区间为1.1~1.3，p值为0.004，随机效应模型中95%可信区间为1.0~1.5，p值为0.056)。在使用固定效应和随机效应模型的混合年龄组中，rs20541的A等位基因与AR发病几率增加相关。IL13SNP rs1800925和IL4R SNP 1801275未显示出与AR的总体关联。我们的结论是，有证据表明IL13SNP rs20541与AR风险增加总体上存在关联，特别是在混合年龄人群中。
P>There is a significant genetic contribution to allergic rhinitis (AR). Genetic association studies for AR have been performed, but varying results make it challenging to decipher the overall potential effect of specific variants. The Th2 pathway plays an important role in the immunological development of AR. We performed meta-analyses of genetic association studies of variants in Th2 pathway genes and AR. PubMed and Phenopedia were searched by double extraction for original studies on Th2 pathway-related genetic polymorphisms and their associations with AR. A meta-analysis was conducted on each genetic polymorphism with data meeting our predetermined selection criteria. Analyses were performed using both fixed and random effects models, with stratification by age group, ethnicity, and AR definition where appropriate. Heterogeneity and publication bias were assessed. Six independent studies analyzing three candidate polymorphisms and involving a total of 1596 cases and 2892 controls met our inclusion criteria. Overall, the A allele of IL13 single nucleotide polymorphism (SNP) rs20541 was associated with increased odds of AR (estimated OR = 1.2; 95% CI 1.1-1.3, p-value 0.004 in fixed effects model, 95% CI 1.0-1.5, p-value 0.056 in random effects model). The A allele of rs20541 was associated with increased odds of AR in mixed age groups using both fixed effects and random effects modeling. IL13 SNP rs1800925 and IL4R SNP 1801275 did not demonstrate overall associations with AR. We conclude that there is evidence for an overall association between IL13 SNP rs20541 and increased risk of AR, especially in mixed-age populations.