Can subretinal microphotodiodes successfully replace degenerated photoreceptors?
Can subretinal microphotodiodes successfully replace degenerated photoreceptors?
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DOI：
10.1016/s0042-6989(98)00312-5
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发表时间：
1999-07-01
期刊：
影响因子：
1.8
通讯作者：
Haemmerle, H
中科院分区：
文献类型：
--
作者：
Zrenner, E;Stett, A;Haemmerle, H
植入微光电二极管阵列作为视觉假体的想法从出现在印刷品的那一刻起就引起了对其可行性的争论。我们现在提出的结果基本上支持视网膜下植入刺激装置取代受损的光感受器的概念。离体大鼠视网膜局部电刺激可调控变性视网膜的神经网络活动。我们还研究了视网膜下植入物的长期稳定性和生物相容性及其对大鼠视网膜生理学的影响。Ganzfeld视网膜电图和组织学显示视网膜下植入物对视网膜功能或内层视网膜结构没有显著的副作用。(C)1999 Elsevier Science Ltd.保留所有权利。
The idea of implanting microphotodiode arrays as visual prostheses has aroused controversy on its feasibility from the moment it appeared in print. We now present results which basically support the concept of replacing damaged photoreceptors with subretinally implanted stimulation devices. Network activity in degenerated rat retinae could be modulated through local electrical stimulation in vitro. We also investigated the long term stability and biocompatibility of the subretinal implants and their impact on retinal physiology in rats. Ganzfeld electroretinograms and histology showed no significant side effect of subretinal implants on retinal function or the architecture of the inner retina. (C) 1999 Elsevier Science Ltd. All rights reserved.