Modeling in vivo pharmacokinetics and pharmaco dynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system
Modeling in vivo pharmacokinetics and pharmaco dynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system
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DOI：
10.1128/aac.49.2.853-856.2005
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发表时间：
2005-02-01
影响因子：
4.9
通讯作者：
Bishai, WR
中科院分区：
文献类型：
--
作者：
Ginsburg, AS;Lee, J;Bishai, WR
为了研究利福沙星治疗结核病的疗效，我们利用一种新型药筒系统来模拟体内药代动力学。我们发现这个系统是一个强大的方法，在体内药代动力学建模和目前的数据支持的效用间歇性氟沙星治疗的抗结核化疗的一部分。
To study the efficacy of moxifloxacin treatment for tuberculosis, we utilized a novel cartridge system to simulate in vivo pharmacokinetics. We found this system to be a robust method for modeling in vivo pharmacokinetics and present data supporting the utility of intermittent moxifloxacin treatment as a component of antituberculosis chemotherapy.