Clinical utility of the anti-CCP assay -: Experiences with 700 patients
Clinical utility of the anti-CCP assay -: Experiences with 700 patients
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DOI：
10.1196/annals.1313.033
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Gaubitz, M
中科院分区：
文献类型：
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作者：
Sauerland, U;Becker, H;Gaubitz, M
我们的目的是确定一系列风湿性疾病患者中环瓜氨酸肽（ccp）抗体的频率。对门诊病人的700个连续血清样本进行类风湿因子（RF）和抗ccp的检测。临床诊断、放射学信息和其他实验室数据均取自患者的病历。抗ccp反应性诊断类风湿关节炎（RA）的敏感性和特异性分别为74.0%和94.5%；RF的敏感性为69.7%，特异性为81.0%。假阳性率最高的是SLE患者（18.3% vs. 12.7% CCP）、Sjdgren综合征（73.3% vs. 3.3% CCP）和慢性肝炎对照组（24.7% vs. 1.3% CCP）。与R-F相比，anti-CCP的检测具有相似的敏感性和更高的特异性，有助于RA的诊断。anti-CCP与R-F相比，通过降低假阳性率，有助于其他炎症性和非炎症性疾病（特别是结缔组织疾病）的诊断。
Our objective was to determine the frequency of antibodies to cyclic citrullinated peptides (CCPs) in a series of patients with a variety of rheumatic diseases. Seven hundred consecutive serum samples from patients at an outpatient clinic were tested for the presence of rheumatoid factor (RF) and anti-CCP. Clinical diagnosis, radiographic information, and other laboratory data were taken from patients' charts. The sensitivity and specificity of anti-CCP reactivity for the diagnosis of rheumatoid arthritis (RA) were 74.0% and 94.5%, respectively; the corresponding results for RF were 69.7% sensitivity and 81.0 % specificity. Highest rates of false-positive RF tests were found in patients with SLE (18.3% vs. 12.7% CCP), Sjdgren's syndrome (73.3% vs. 3.3% CCP), and a control group with chronic hepatitis (24.7% vs. 1.3% CCP). The detection of anti-CCP is useful for the diagnosis of RA because of its similar sensitivity but higher specificity compared with RE Anti-CCP also helps to diagnose other inflammatory and noninflammatory diseases (especially connective tissue diseases) by reducing the rate of false-positive results in comparison with R-F.