Nuclear targeting of SV40 and adenovirus
Nuclear targeting of SV40 and adenovirus
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DOI：
10.1016/0962-8924(96)10016-7
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发表时间：
1996-05-01
影响因子：
19
通讯作者：
Kasamatsu, H
中科院分区：
文献类型：
--
作者：
Greber, UF;Kasamatsu, H
将病毒DNA导入细胞核对于DNA肿瘤病毒的成功复制至关重要。为了实现这一目标，病毒已经调整了策略来穿越宿主细胞质膜和细胞核之间的屏障。两种DNA肿瘤病毒，猿猴病毒40和腺病毒，以略微不同的方式实现核进入步骤。SV40 DNA在表面上完整的病毒体中通过核孔复合物（NPC）进入细胞核。相比之下，腺病毒颗粒在病毒DNA输入细胞核之前在NPC附近解离。在这两种情况下，病毒的亲核蛋白组分似乎介导病毒基因组的核进入。在这篇文章中，我们讨论了如何理解的细胞生物学的vints进入可以帮助我们理解的过程中的核运输。
Import of viral DNA into the nucleus is essential for the successful replication of DNA tumour viruses. To achieve this goal, viruses have adapted strategies to traverse the barriers between the plasma membrane and the nucleus of a host cell. Two DNA tumour viruses, simian virus 40 and adenovirus, achieve the nuclear-entry step in slightly different ways. SV40 DNA enters the nucleus through the nuclear pore complexes (NPCs) in apparently intact virions. By contrast, adenovirus particles dissociate near the NPC before the viral DNA is imported into the nucleus. In both cases, karyophilic protein components of the viruses appear to mediate nuclear entry of the viral genomes. In this article, we discuss how an understanding of the cell biology of vints entry can help us understand the process of nuclear transport.