Obesity, inflammation, and lung injury (OILI): the good.
Obesity, inflammation, and lung injury (OILI): the good.
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DOI：
10.1155/2014/978463
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发表时间：
2014
影响因子：
4.6
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Wang C
肥胖成为流行病，使这些人有极大的肺损伤风险。本文从脂肪细胞因子与肥胖、炎症与其他机制、脂肪细胞因子与炎症连接的肥胖症肺损伤、潜在的治疗靶点等几个方面对抗炎药物进行了综述。综上所述，大多数证据支持肥胖患者脂联素、omentin和分泌的卷曲相关蛋白5显著减少，这与炎症增加有关，表现为肿瘤坏死因子α和IL-6通过激活Toll样受体和核因子轻链κB(NF-κB)信号通路而增加。服用这些脂肪细胞因子可促进减肥和减少炎症。ZAG、VASPIN、IL-10、IL-1RA、转化生长因子β、生长分化因子15等也被认为具有抗炎作用。有一些有争议的报道。此外，关于肥胖引起的肺损伤的研究也非常缺乏。脂联素对肺移植、哮喘、慢性阻塞性肺疾病(COPD)和肺炎的作用在肺损伤中具有抗炎和保护作用。给予IL-10激动剂可降低急性坏死性胰腺炎兔急性肺损伤的死亡率，可能是通过抑制炎症反应和增强宿主免疫来实现的。关于其他脂肪细胞因子的信息非常有限。
Obesity becomes pandemic, predisposing these individuals to great risk for lung injury. In this review, we focused on the anti-inflammatories and addressed the following aspects: adipocytokines and obesity, inflammation and other mechanisms, adipocytokines and lung injury in obesity bridged by inflammation, and potential therapeutic targets. To sum up, the majority of evidence supported that adiponectin, omentin, and secreted frizzled-related protein 5 (SFRP5) were reduced significantly in obesity, which is associated with increased inflammation, indicated by increase of TNFα and IL-6, through activation of toll-like receptor (TLR4) and nuclear factor light chain κB (NF-κB) signaling pathways. Administration of these adipocytokines promotes weight loss and reduces inflammation. Zinc-α2-glycoprotein (ZAG), vaspin, IL-10, interleukin-1 receptor antagonist (IL-1RA), transforming growth factor β (TGF-β1), and growth differentiation factor 15 (GDF15) are also regarded as anti-inflammatories. There were controversial reports. Furthermore, there is a huge lack of studies for obesity related lung injury. The effects of adiponectin on lung transplantation, asthma, chronic obstructive pulmonary diseases (COPD), and pneumonia were anti-inflammatory and protective in lung injury. Administration of IL-10 agonist reduces mortality of acute lung injury in rabbits with acute necrotizing pancreatitis, possibly through inhibiting proinflammation and strengthening host immunity. Very limited information is available for other adipocytokines.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
7.7
作者：
Carstensen M;Herder C;Kivimäki M;Jokela M;Roden M;Shipley MJ;Witte DR;Brunner EJ;Tabák AG
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影响因子：
6
作者：
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通讯作者：
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影响因子：
4.1
作者：
Gao, D.;Trayhurn, P.;Bing, C.
通讯作者：
Bing, C.
DOI：
10.1056/nejmoa0807865
发表时间：
2009-06-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Aksentijevich I;Masters SL;Ferguson PJ;Dancey P;Frenkel J;van Royen-Kerkhoff A;Laxer R;Tedgård U;Cowen EW;Pham TH;Booty M;Estes JD;Sandler NG;Plass N;Stone DL;Turner ML;Hill S;Butman JA;Schneider R;Babyn P;El-Shanti HI;Pope E;Barron K;Bing X;Laurence A;Lee CC;Chapelle D;Clarke GI;Ohson K;Nicholson M;Gadina M;Yang B;Korman BD;Gregersen PK;van Hagen PM;Hak AE;Huizing M;Rahman P;Douek DC;Remmers EF;Kastner DL;Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R