Familial clustering of ovarian and endometrial cancers
Familial clustering of ovarian and endometrial cancers
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DOI：
10.1016/s0959-8049(03)00627-0
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发表时间：
2004-01-01
影响因子：
8.4
通讯作者：
Granström, C
中科院分区：
文献类型：
--
作者：
Hemminki, K;Granström, C
关于卵巢癌与家族中其他癌症相关性的数据有限，并且没有关于特定形态类型的参与的数据。瑞典全国性家庭癌症数据库中有1020万人和19175例浸润性卵巢癌，用于计算0-66岁女儿的标准化发病率（SIR）和95%置信区间（CI），当母亲或姐妹篇受到影响时。一致性卵巢癌的SIR增加。当母亲或姐妹患有乳腺癌时，SIR分别为1.21和1.48;当她们患有子宫内膜癌时，SIR分别为1.45和2.53。母亲的多发性骨髓瘤与女儿患卵巢癌的风险相关。当母亲患有子宫内膜癌时，女儿患卵巢癌的风险为3.40。我们的数据显示卵巢癌和子宫内膜癌有很强的家族性偶联，这似乎是卵巢样形态所特有的。(C)2003 Elsevier Ltd.保留所有权利。
Data on the association of ovarian cancer with other cancers in families are limited, and no data are available on the involvement of specific morphological types. The nationwide Swedish Family-Cancer Database on 10.2 million individuals and 19 175 invasive ovarian cancers was used to calculate standardised incidence ratios (SIRs) and 95% confidence intervals (CIs) for familial ovarian cancer in 0-66-year-old daughters when mothers or sisters were affected. The SIR for concordant ovarian cancers was increased. When the mother or sister had breast cancer, the SIRs were 1.21 and 1.48, respectively; when they had endometrial cancer, the SIRs were 1.45 and 2.53. Multiple myeloma in the mother was associated with a risk of ovarian cancer in the daughter. The risk of endometrioid ovarian cancer was 3.40 in the daughter when the mother presented with endometrial cancer. Our data show a strong familial coupling of ovarian and endometrial cancers, which appears to be specific to the endometrioid morphology. (C) 2003 Elsevier Ltd. All rights reserved.