A retrospective evaluation of radiation dose associated with low dose FDG protocols in whole-body PET/CT
A retrospective evaluation of radiation dose associated with low dose FDG protocols in whole-body PET/CT
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DOI：
10.1007/s13246-011-0119-8
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发表时间：
2012-03-01
影响因子：
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通讯作者：
Bailey, Dale L.
中科院分区：
文献类型：
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作者：
Willowson, Kathy P.;Bailey, Elizabeth A.;Bailey, Dale L.
本研究的目的是回顾性测量在Siemens Biograph mCT扫描仪上使用低剂量方案进行的全身X射线CT和FDG PET研究产生的患者辐射剂量。共审查了483项患者研究。对于每种情况，使用CT剂量长度乘积估计PET/CT研究的全身X射线CT部分对患者造成的辐射剂量。根据ICRP的建议，使用净注射FDG剂量来计算全身有效剂量。还修改了剂量计算，以考虑个体患者体重。每例患者接受的总有效剂量为研究的PET和CT部分的总和。诊断研究的CT部分的平均有效剂量为8.2 mSv（3.4-23.4 mSv），CT方案为120 kV（p），有效管电流-时间乘积为80 mAs，自动曝光控制。对于304 MBq的平均注射FDG活性，当使用ICRP标准模型时，发现平均PET有效剂量为6.3 mSv，或者当将有效剂量缩放到个体患者体重或患者血容量时，发现平均PET有效剂量为6.0 mSv。在PET/CT联合研究中，整个患者队列的平均总有效剂量与14.5 mSv（9.6-29.8 mSv）相似。全身PET/CT扫描的低剂量方案导致患者的有效辐射剂量约为14.5 mSv。通过使用迭代CT重建和优化的低剂量FDG协议，可以看到全身PET/CT的总有效剂量降至10 mSv以下。
The objective of the study is to retrospectively measure patient radiation dose resulting from whole body X-ray CT and FDG PET studies using a low-dose protocol performed on the Siemens Biograph mCT scanner. A total of 483 patient studies were reviewed. For each, the CT dose-length product was used to estimate radiation dose to the patient as a result of the whole body X-ray CT component of the PET/CT study. The net injected FDG dose was used to calculate the whole body effective dose based on ICRP recommendations. Dose calculations were also modified to take into account individual patient weight. The total effective dose received by each patient was taken as the sum of the PET and CT components of the study. The mean effective dose from the CT component of the diagnostic study was found to be 8.2 mSv (3.4-23.4 mSv), for a CT protocol of 120 kV(p) and effective tube current-time product of 80 mAs with automatic exposure control. For an average injected FDG activity of 304 MBq the mean PET effective dose was found to be 6.3 mSv when using the ICRP standard models, or 6.0 mSv when scaling effective dose to individual patient weight or patient blood volume. The average total effective dose across the entire patient cohort for a combined PET/CT study was found to be similar to 14.5 mSv (9.6-29.8 mSv). Low-dose protocols for whole-body PET/CT scanning result in an effective radiation dose to the patient of approximately 14.5 mSv. Additional reductions through the use of iterative CT reconstruction and optimized low-dose FDG protocols could see total effective doses for whole-body PET/CT fall to below 10 mSv.