Regiospecific Intermolecular Aminohydroxylation of Olefins by Photoredox Catalysis
Regiospecific Intermolecular Aminohydroxylation of Olefins by Photoredox Catalysis
复制标题
DOI：
10.1002/chem.201501590
复制
发表时间：
2015-08-10
影响因子：
4.3
通讯作者：
Akita, Munetaka
中科院分区：
文献类型：
--
作者：
Miyazawa, Kazuki;Koike, Takashi;Akita, Munetaka
本文报道了一种简单的、区域专一的烯烃氨羟化反应。N-保护的1-氨基吡啶盐是关键化合物，通过Ir光催化剂fac-[Ir（ppy）（3）]和[Ir（ppy）（2）（dtbbpy）]（PF 6）（ppy=2-吡啶基苯基，dtbbpy= 4，4-二叔丁基-2，2-联吡啶）的作用作为酰胺基自由基前体。本发明的光催化体系允许在温和的反应条件下由具有各种官能团的烯烃合成邻氨基醇衍生物，易于处理。
A simple and regiospecific aminohydroxylation of olefins by photoredox catalysis has been developed. N-protected 1-aminopyridinium salts are the key compounds and serve as amidyl radical precursors by the action of Ir photocatalysts, fac-[Ir(ppy)(3)] and [Ir(ppy)(2)(dtbbpy)](PF6) (ppy=2-pyridylphenyl, dtbbpy=4,4-di-tert-butyl-2,2-bipyridine). The present photocatalytic system allows for synthesis of vicinal aminoalcohol derivatives from olefins with various functional groups under mild reaction conditions with easy handling.