Colonization, bloodstream infection, and mortality caused by vancomycin-resistant enterococcus early after allogeneic hematopoietic stem cell transplant
Colonization, bloodstream infection, and mortality caused by vancomycin-resistant enterococcus early after allogeneic hematopoietic stem cell transplant
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DOI：
10.1016/j.bbmt.2007.01.078
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发表时间：
2007-05-01
影响因子：
4.3
通讯作者：
Zuccotti, Gianna
中科院分区：
文献类型：
--
作者：
Weinstock, David M.;Conlon, Mary;Zuccotti, Gianna
万古霉素耐药肠球菌（VRE）引起的血流感染与异基因造血干细胞移植（alloHSCT）受者的高死亡率相关。然而，目前尚不清楚VRE血流感染是否直接导致移植后早期死亡，或者仅仅是预后不良的标志。为了确定VRE血流感染的危险因素及其对结果的影响，我们随访了92例在接受alloHSCT时通过VRE筛查粪便定植的患者。审查患者记录以确定结局，包括死亡率和微生物学失败。VRE定植极为常见，发生在40.2%的患者中。VRE定植组34.2%的患者在第35天发生VRE血流感染，而无VRE定植组仅1.8%（P
Bloodstream infection caused by vancomycin-resistant enterococcus (VRE) is associated with very high mortality among allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. However, it remains unclear whether VRE bloodstream infection directly causes mortality in the early posttransplant period or is simply a marker of poor outcome. To determine the risk factors for VRE bloodstream infection and its effect on outcome, we followed 92 patients screened for stool colonization by VRE upon admission for alloHSCT. Patient records were reviewed to determine outcomes, including mortality and microbiologic failure. Colonization by VRE was extremely common, occurring in 40.2 % of patients. VRE bloodstream infection developed in 34.2% of colonized patients by day +35, compared to 1.8% without VRE colonization (P