Improving selectivity of ion-sensitive membrane by polyethylene glycol doping
Improving selectivity of ion-sensitive membrane by polyethylene glycol doping
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DOI：
10.1016/j.snb.2020.128955
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发表时间：
2021-02-01
影响因子：
8.4
通讯作者：
Zhang, Zhen
中科院分区：
文献类型：
--
作者：
Hu, Qitao;Chen, Si;Zhang, Zhen
由于疏水相互作用，疏水离子会对基于膜的离子选择性传感器的复杂分析物中的离子检测产生相当大的干扰。在本文中，我们证明通过将亲水性聚乙二醇（PEG）掺入膜中可以显着减少疏水相互作用对传感器的干扰。该传感器是一种硅纳米线场效应晶体管 (SiNWFET)，其表面采用离子载体掺杂混合基质膜 (MMM) 进行功能化，其中离子载体可以是商业钠离子载体 III，也可以是新型合成金属有机超级容器。 PEG 的掺入抑制了疏水性离子在 MMM 中的分配，从而减少了它们对目标离子检测的干扰。在存在干扰亚甲基蓝 (MB+) 离子的情况下，Na+ 检测的选择性提高了一个数量级以上，这证明了这一点。它还能够使用 SiNWFET 传感器阵列以复用方式检测 Na+ 和 MB+，并具有受控的交叉干扰敏感性和极大扩展的动态范围。
Hydrophobic ions can generate considerable interference to ion detection in a complex analyte with membrane-based ion-selective sensors, due to the hydrophobic interaction. In this paper, we demonstrate that the interference from the hydrophobic interaction to the sensors can be significantly reduced by incorporating hydrophilic polyethylene glycol (PEG) into the membrane. The sensor is a silicon nanowire field-effect transistor (SiNWFET) with its surface functionalized with an ionophore-doped mixed-matrix membrane (MMM), where the ionophore is either a commercial Na-ionophore III or a novel synthetic metal-organic supercontainer. The incorporation of PEG suppresses the partitioning of hydrophobic ions into the MMM and thus reduces their interference to the detection of target ions. This is evidenced with an improvement in selectivity for Na+ detection in the presence of interfering methylene blue (MB+) ion by more than an order of magnitude. It further enables detection of Na+ and MB+ using a SiNWFET sensor array in a multiplexed manner with controlled susceptivity to cross-interference and a greatly expanded dynamic range.