THE VITESSE ALGORITHM FOR RAPID EXACT MULTILOCUS LINKAGE ANALYSIS VIA GENOTYPE SET-RECODING AND FUZZY INHERITANCE
THE VITESSE ALGORITHM FOR RAPID EXACT MULTILOCUS LINKAGE ANALYSIS VIA GENOTYPE SET-RECODING AND FUZZY INHERITANCE
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DOI：
10.1038/ng1295-402
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发表时间：
1995-12-01
期刊：
影响因子：
30.8
通讯作者：
WEEKS, DE
中科院分区：
文献类型：
--
作者：
OCONNELL, JR;WEEKS, DE
随着遗传标记图谱的改进，多点连锁分析已成为所有疾病图谱研究的重要组成部分。自相矛盾的是，多点杆评分变得越来越难以计算，特别是随着标记、标记等位基因和未分型人群数量的增加。我们已经解决了这个问题，通过使用一种新的集合重新编码方案来重新编码每个人的基因型和“模糊遗传”来推断传输概率。我们的方法是实现在一个内存效率的计算机程序，VITESSE，非常快速的计算精确的多点似然。VITESSE能够利用高度多态性标记快速、精确地对疾病位点进行多点定位。
As genetic marker maps have improved, multipoint linkage analysis has become a crucial part of all disease mapping studies. Paradoxically, multipoint rod scores become increasingly difficult to compute, particularly as the numbers of markers, marker alleles and untyped people increase. We have solved this problem by using a novel set-recoding scheme to recode each person's genotype and 'fuzzy inheritance' to infer transmission probabilities. Our approach is implemented in a memory-efficient computer program, VITESSE, for extremely rapid computation of exact multipoint likelihoods. VITESSE enables fast and precise multipoint mapping of disease loci with highly polymorphic markers.