Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala
Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala
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DOI：
10.3945/ajcn.2010.29686
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发表时间：
2010-11-01
影响因子：
7.1
通讯作者：
Stein, Aryeh D.
中科院分区：
文献类型：
--
作者：
DiGirolamo, Ann M.;Zea, Manuel Ramirez;Stein, Aryeh D.
背景 全世界儿童的精神疾病发病率正在增加 对抑郁、焦虑和注意力缺陷多动障碍的观察性研究表明，锌是一种替代治疗方法 目的 我们研究了补充锌对危地马拉学龄儿童心理健康的影响 设计 从 2006 年 1 月到 10 月，我们进行了一项为期 6 个月的随机双盲对照试验，比较非补充锌（每天 10 毫克氧化锌，持续 5 天/周）与安慰剂（10 毫克葡萄糖）的情况674 名 1-4 年级危地马拉儿童 结果测量包括实习时间（即抑郁和焦虑）和外化（即多动和品行障碍）、问题行为、积极行为（如社交和领导力）和血清锌浓度 结果 锌组和安慰剂组在基线或随访时的任何行为测量中没有显着差异 在基线 21 时，4% 的儿童有血清锌浓度
Background Rates of mental illness in children are increasing throughout the world Observational studies of depression anxiety and attention-deficit hyperactivity disorder suggest that zinc is an alternative treatmentObjective We examined the effect of zinc supplementation on the mental health of school-age children in GuatemalaDesign From January to October 2006 we conducted a 6 mo randomized double blind controlled trial comparing zinc supplementation non (10 mg ZnO/d for 5 d/wk) with a placebo (10 mg glucose) in 674 Guatemalan children in grades 1-4 Outcome measures included intern timing (ie depression and anxiety) and externalizing (ie hyper activity and conduct disorder) problem behaviors positive behaviors (le socialization and leadership) and serum zinc concentrationsResults Zinc and placebo groups did not differ significantly in any behavioral measures at baseline or at follow up At baseline 21 4% of children had serum zinc concentrations