Iatrogenic Creutzfeldt-Jakob disease and its neurosurgical implications
Iatrogenic Creutzfeldt-Jakob disease and its neurosurgical implications
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DOI：
10.1016/s0967-5868(96)90003-x
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发表时间：
1996-04-01
影响因子：
2
通讯作者：
Tannenberg, AEG
中科院分区：
文献类型：
--
作者：
Simpson, DA;Masters, CL;Tannenberg, AEG
克雅氏病（CJD）已被报道后，硬脑膜同种移植物插入。两个澳大利亚病例的克雅氏病，都在后颅窝开颅手术在1982年完成，报告，潜伏期分别为5年和12年。这种关联似乎极有可能是因果关系。CJD感染因子（朊病毒）对许多先前接受的灭菌方法具有抗性，并且假定尸体硬脑膜材料来自CJD受试者，或者在制备过程中被污染。在澳大利亚，在神经外科中使用硬脑膜同种移植物于1987年被放弃;因为平均潜伏期（根据一项世界范围的审查确定）已经进行了大约65个月，现在希望：克雅氏病的病因不会在澳大利亚人群中复发，尽管现在断言这一点还为时过早，但是，预防病例间传播的预防措施仍然是必要的，在手术实践和器官捐赠中应执行这方面的准则。(C)Pearson Professional 1996.
Creutzfeldt-Jakob (CJD) disease has been reported after the insertion of dural homografts. Two Australian cases of CJD, both following posterior fossa craniotomies done in 1982, are reported; the incubation periods were 5 and 12 years. It seems highly probable that the association is causal. CJD infective agents (prions) are resistant to many previously accepted means of sterilisation and it is postulated that cadaver dural material was either derived from subjects with CJD, or was contaminated during preparation, In Australia the use of dural homografts in neurosurgery was abandoned in 1987; as the mean incubation period (determined from a world-wide review) has been about 65 months, it is now hoped that this: cause of CJD will not recur in the Australian population, although it is premature to state this with confidence, However, precautions against case-to-case transmission remain necessary, and guidelines for this purpose should be enforced in theatre practice and in organ donations. (C) Pearson Professional 1996.