Inflammation and frailty in older women
Inflammation and frailty in older women
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DOI：
10.1111/j.1532-5415.2007.01186.x
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发表时间：
2007-06-01
影响因子：
6.3
通讯作者：
Fried, Linda P.
中科院分区：
文献类型：
--
作者：
Leng, Sean X.;Xue, Qian-Li;Fried, Linda P.
目的：为了评估白色血细胞（WBC）计数和白细胞介素-6（IL-6）与普遍虚弱之间的关系。设计：横断面研究。设置：两项基于人群的研究，妇女健康与衰老研究（WHAS）I和II，巴尔的摩，马里兰州。参与者：558名年龄在65至101岁之间的妇女来自WHAS I，548名年龄在70至79岁之间的妇女来自合并的WHAS I和II coherents.Measurements：使用经验证的筛选标准确定虚弱。使用标准实验室方法测量WBC计数和IL-6水平。在基线WBC计数和IL-6水平的三分位数中评估虚弱的比值比（OR），调整年龄、种族、教育、体重指数和吸烟状况。在WHAS I中，WBC计数和IL-6的前三分位数的患者的OR为4.25（95%CI =1.89-9.58）和3.98（95%CI =1.76-9.00）（均P
Objectives: To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty.Design: Cross-sectional study.Setting: Two population-based studies, the Women's Health and Aging Studies (WHAS) I and II, Baltimore, Maryland.Participants: Five hundred fifty-eight women aged 65 to 101 from WHAS I and 548 women aged 70 to 79 from the merged WHAS I and II cohorts.Measurements: Frailty was determined using validated screening criteria. WBC counts and IL-6 levels were measured using standard laboratory methods. Odds ratios (ORs) for frailty were evaluated across tertiles of baseline WBC counts and IL-6 levels, adjusting for age, race, education, body mass index, and smoking status.Results: In WHAS I, those in the top tertile of WBC count and IL-6 had ORs of 4.25 (95% confidence interval (CI)=1.89-9.58) and 3.98 (95% CI=1.76-9.00), respectively, for frailty (both P