Gene regulation by nuclear and cytoplasmic calcium signals
Gene regulation by nuclear and cytoplasmic calcium signals
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DOI：
10.1006/bbrc.1997.7037
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发表时间：
1997-07-30
影响因子：
3.1
通讯作者：
Chawla, S
中科院分区：
文献类型：
--
作者：
Bading, H;Hardingham, GE;Chawla, S
钙通过 N-甲基-D-天冬氨酸 (NMDA) 型谷氨酸受体或 L 型电压门控钙通道进入神经元细胞是电激活后控制基因表达的关键事件。钙在细胞质和细胞核中发挥作用，激活信号通路，通过不同的 DNA 调控元件刺激基因表达。空间上不同的钙信号对转录的差异控制提供了一种机制，通过该机制单个第二信使可以产生不同的转录反应。这可能允许对基因表达进行刺激特异性调节，这对于神经系统的适应性变化至关重要。 (C) 1997 年学术出版社。
Calcium entry into neuronal cells through N-methyl-D-aspartate (NMDA)-type glutamate receptors or L-type voltage-gated calcium channels is a key event in the control of gene expression following electrical activation. Calcium acts both in the cytoplasm and the nucleus to activate signalling pathways that stimulate gene expression through different DNA regulatory elements. Differential control of transcription by spatially distinct calcium signals provides a mechanism by which a single second messenger can generate diverse transcriptional responses. This may allow for stimulation-specific modulation of gene expression critical for adaptive changes in the nervous system. (C) 1997 Academic Press.