Differential production of and migratory response to beta chemokines by human microglia and astrocytes
Differential production of and migratory response to beta chemokines by human microglia and astrocytes
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DOI：
10.1093/infdis/175.2.478
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发表时间：
1997-02-01
影响因子：
6.4
通讯作者：
Chao, CC
中科院分区：
文献类型：
--
作者：
Peterson, PK;Hu, SX;Chao, CC
关于β趋化因子在中枢神经系统炎症过程中的作用，人们知之甚少。用脂多糖、白介素1β和肿瘤坏死因子α刺激培养的人胎儿小胶质细胞和星形胶质细胞，检测其中三种多肽(巨噬细胞炎性蛋白[MIP]-1α、MIP-1β和单核细胞趋化蛋白-1)的释放。尽管这两种类型的胶质细胞对脂多糖和细胞因子的反应性有显著差异，但小胶质细胞和星形胶质细胞都能产生所有三种β趋化因子。然而，只有小胶质细胞对β趋化因子表现出更强的迁移反应。这项体外研究的结果表明，β趋化因子可能在单核巨噬细胞在脑内的运输中发挥重要作用。
Little is known about the participation of beta chemokines in inflammatory processes within the central nervous system. The release of three of these peptides (macrophage inflammatory protein [MIP]-1 alpha, MIP-1 beta, and monocyte chemoattractant protein-1) from human fetal microglial cell and astrocyte cultures was assessed following stimulation by lipopolysaccharide, interleukin-1 beta, and tumor necrosis factor-alpha. Although striking differences were found between these two types of glial cells in their responsiveness to lipopolysaccharide and cytokines, both microglia and astrocytes produced all three beta chemokines. Only microglial cells, however, demonstrated an increased migratory response to the beta chemokines. The results of this in vitro study suggest that beta chemokines may play an important role in the trafficking of mononuclear phagocytes within the brain.